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Rigshospitalet - a part of Copenhagen University Hospital
Published

Fighting Cancer Using an Oncofetal Glycosaminoglycan-Binding Protein from Malaria Parasites

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DOI

  1. Precipitated Malaria: It Never Rains but It Pours

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  2. Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria

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  3. Rifins, rosetting, and red blood cells

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  4. Trying to remember: immunological B cell memory to malaria

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  5. Monitoring antifolate resistance in intermittent preventive therapy for malaria

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  1. Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine

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Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.

Original languageEnglish
JournalTrends in Parasitology
Volume35
Issue number3
Pages (from-to)178-181
Number of pages4
ISSN1471-4922
DOIs
Publication statusPublished - Mar 2019

    Research areas

  • Antigens, Neoplasm/metabolism, Antigens, Protozoan/genetics, Chondroitin Sulfates/metabolism, Neoplasms/diagnosis, Plasmodium/chemistry, Recombinant Proteins/genetics

ID: 59238925