Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Validation of the four-miRNA biomarker panel MiCaP for prediction of long-term prostate cancer outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Four-point impedance as a biomarker for bleeding during cochlear implantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Fatal pneumococcus meningitis in a child with complement factor ficolin-3 deficiency

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Circulating cell free DNA during definitive chemo-radiotherapy in non-small cell lung cancer patients - initial observations

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection. In addition, an immune modulatory role of ficolins has been suggested. Yet, the contribution of ficolins to inflammatory disease processes remains elusive. To address this, we investigated ficolin deficient mice during a lipopolysaccharide (LPS)-induced model of systemic inflammation. Although murine serum ficolin was shown to bind LPS in vitro, there was no difference between wildtype and ficolin deficient mice in morbidity and mortality by LPS-induced inflammation. Moreover, there was no difference between wildtype and ficolin deficient mice in the inflammatory cytokine profiles after LPS challenge. These findings were substantiated by microarray analysis revealing an unaltered spleen transcriptome profile in ficolin deficient mice compared to wildtype mice. Collectively, results from this study demonstrate that ficolins are not involved in host response to LPS-induced systemic inflammation.

Original languageEnglish
JournalScientific Reports
Volume7
Issue number1
Pages (from-to)e3852
ISSN2045-2322
DOIs
Publication statusPublished - 20 Jun 2017

    Research areas

  • Journal Article

ID: 52367755