Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long QT syndrome type 1 and 2 patients respond differently to arrhythmic triggers: The TriQarr in vivo study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Detection of atrial fibrillation with implantable loop recorders in horses

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Symptoms Preceding Sports-Related Sudden Cardiac Death in Persons Aged 1-49 Years

    Research output: Contribution to journalReviewpeer-review

  3. Symptoms and healthcare contact preceding sudden cardiac death in persons aged 1-49 years

    Research output: Contribution to journalReviewpeer-review

  • Yoav Michowitz
  • Anat Milman
  • Georgia Sarquella-Brugada
  • Antoine Andorin
  • Jean Champagne
  • Pieter G Postema
  • Ruben Casado-Arroyo
  • Eran Leshem
  • Jimmy J M Juang
  • Carla Giustetto
  • Jacob Tfelt-Hansen
  • Yanushi D Wijeyeratne
  • Christian Veltmann
  • Domenico Corrado
  • Sung-Hwan Kim
  • Pietro Delise
  • Shingo Maeda
  • Jean-Baptiste Gourraud
  • Frederic Sacher
  • Philippe Mabo
  • Yoshihide Takahashi
  • Tsukasa Kamakura
  • Takeshi Aiba
  • Giulio Conte
  • Aviram Hochstadt
  • Yuka Mizusawa
  • Michael Rahkovich
  • Elena Arbelo
  • Zhengrong Huang
  • Isabelle Denjoy
  • Carlo Napolitano
  • Ramon Brugada
  • Leonardo Calo
  • Silvia G Priori
  • Masahiko Takagi
  • Elijah R Behr
  • Fiorenzo Gaita
  • Gan-Xin Yan
  • Josep Brugada
  • Antoine Leenhardt
  • Arthur A M Wilde
  • Pedro Brugada
  • Kengo F Kusano
  • Kenzo Hirao
  • Gi-Byoung Nam
  • Vincent Probst
  • Bernard Belhassen
View graph of relations

BACKGROUND: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series.

OBJECTIVE: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS.

METHODS: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252).

RESULTS: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3-76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0-5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years.

CONCLUSION: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.

Original languageEnglish
JournalHeart Rhythm
Volume15
Issue number9
Pages (from-to)1394-1401
Number of pages8
ISSN1547-5271
DOIs
Publication statusPublished - Sep 2018

ID: 56382074