Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Familial Hypercholesterolemia and Risk of Peripheral Arterial Disease and Chronic Kidney Disease

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effect of the incretin hormones on the endocrine pancreas in end-stage renal disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Gene Expression in Granulosa Cells From Small Antral Follicles From Women With or Without Polycystic Ovaries

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Hydroxylated Long-Chain Acylcarnitines are Biomarkers of Mitochondrial Myopathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Impact of LDL cholesterol on microvascular versus macrovascular disease: A Mendelian Randomization Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Response to Letter to the Editor: "Familial hypercholesterolemia and risk of peripheral arterial disease and chronic kidney disease"

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Low LDL cholesterol by PCSK9 variation reduces cardiovascular mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Causal associations in type 2 diabetes development

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Context: Individuals with familial hypercholesterolemia (FH) have a high risk of coronary artery disease, but their risk of peripheral arterial disease (PAD) and chronic kidney disease (CKD) is unknown.

Objective: In individuals with clinical FH, we tested the hypotheses (1) that the risks of PAD and CKD are elevated and (2) that low ankle-brachial index (ABI) and estimated glomerular filtration rate (eGFR) are associated with a high risk of myocardial infarction.

Design and Setting: Prospective cohort study of the general population.

Participants: A total of 106,172 individuals, of whom 7109 were diagnosed with FH.

Main Outcome Measures: PAD, CKD, and myocardial infarction.

Results: Compared with individuals with unlikely FH, multivariable adjusted ORs (95% CIs) of PAD were 1.84 (1.70 to 2.00) in those with possible FH and 1.36 (1.00 to 1.84) in individuals with probable/definite FH. For CKD, the corresponding ORs (95% CIs) were 1.92 (1.78 to 2.07) and 2.42 (1.86 to 3.26). Compared with individuals with unlikely FH and ABI >0.9, the multivariable adjusted hazard ratio (95% CI) of myocardial infarction was 4.60 (2.36 to 8.97) in those with possible/probable/definite FH and ABI ≤0.9. Compared with individuals with unlikely FH and eGFR ≥60 mL/min/1.73 m2, the corresponding value was 2.19 (1.71 to 2.82) in those with possible/probable/definite FH and eGFR <60 mL/min/1.73 m2.

Conclusions: Individuals with clinical FH have increased risks of PAD and CKD, and low ABI and eGFR are associated with high risk of myocardial infarction. Consequently, individuals with FH should be screened for PAD and CKD, and ABI and eGFR may be used as prognostic tools in the management and treatment of FH to identify those at very high risk of myocardial infarction.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume103
Issue number12
Pages (from-to)4491-4500
Number of pages10
ISSN0021-972X
DOIs
Publication statusPublished - 1 Dec 2018

ID: 55738788