Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital

Factors associated with ocular surface disease and severity in adults with atopic dermatitis: a nationwide survey

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Food purchases in households with and without diabetes based on consumer purchase data

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. IL-4 and IL-13 both contribute to the homeostasis of human conjunctival goblet cells in vitro

    Research output: Contribution to journalLetterResearchpeer-review

  3. Mutation of KRAS in colorectal adenocarcinoma in Greenland

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Investigation of the correlation between diabetic retinopathy and prevalent and incident migraine in a national cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Ocular surface diseases (OSDs), including conjunctivitis and blepharitis, are common in atopic dermatitis (AD) patients, but the magnitude and patient characteristics are unclear.

OBJECTIVES: To examine the prevalence of OSDs in adults with AD and identify patient characteristics and risk factors.

METHODS: We designed a cross-sectional questionnaire-based survey and sent it via a secure public mail to all adult Danes with a hospital diagnosis of AD (ICD-10 code L20.x) registered in the National Patient Register (n = 16 718) between 2000 and 2019 and 7044 (42%) participated. Primary outcomes were OSDs and severity according to Ocular Surface Disease Index (OSDI). Adjusted odds ratios (aOR) were calculated with 95% confidence intervals (CIs) using logistic regression models.

RESULTS: Respondents were mostly females and middle-aged (67.4%, mean [SD] age, 39.0 [15.5] years). Based on Patient-Oriented SCORing Atopic Dermatitis 49% had mild AD, 35% moderate, 10% severe and in 6% AD was inactive; 44.3% reported physician-diagnosed asthma bronchiale and 55.8% rhinitis. The lifetime prevalence of OSDs was 66.6% for conjunctivitis, 63.5% for hordeolum, 11.0% for blepharitis, 9.7% for keratitis, 2.0% for pterygium, 1.5% for symblepharon, 1.1% for keratoconus and 12.7% reported current conjunctivitis. Factors associated with lifetime occurrence of conjunctivitis included mild, moderate, and severe AD (aOR = 1.48 [95% CI, 1.02-2.14], aOR = 1.73 [95% CI, 1.19-2.53], aOR = 2.17 [95% CI, 1.42-3.21]), asthma bronchiale and rhinitis (aOR = 1.76 [95% CI, 1.49-2.07]), childhood-onset of AD (aOR = 1.34 [95% CI, 1.16-1.56]) and systemic AD treatment (aOR = 1.27 [95% CI, 1.08-1.50]). Use of soft and hard contact lenses (aOR = 2.15 [95% CI, 1.65-2.80], aOR = 3.35 [95% CI, 1.62-6.92]) were associated with lifetime occurrence of keratitis. Moderate and severe AD, asthma bronchiale and rhinitis were also associated with a higher OSDI level.

CONCLUSIONS: This study identified important patient factors associated with OSDs. Clinicians should be attentive of ocular signs and symptoms in AD patients and ask about these.

Original languageEnglish
JournalJournal of the European Academy of Dermatology and Venereology : JEADV
Issue number4
Pages (from-to)592-601
Number of pages10
Publication statusPublished - Apr 2022

Bibliographical note

© 2021 European Academy of Dermatology and Venereology.

ID: 69996681