Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Factors associated with a cervical high-grade lesion on cytology or a positive visual inspection with acetic acid among more than 3300 Tanzanian women

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Critical evaluation of the appetite test for children with severe acute malnutrition

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition: an observational study in Ethiopia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Physical activity level among children recovering from severe acute malnutrition

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. High prevalence of diabetes and anthropometric heterogeneity among tuberculosis patients in Pakistan

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Endometrial cancer risk after fertility treatment: a population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. HPV types, cervical high-grade lesions and risk factors for oncogenic human papillomavirus infection among 3416 Tanzanian women

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Gynaecological cancer leads to long-term sick leave and permanently reduced working ability years after diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Birgitte Baldur-Felskov
  • Julius Mwaiselage
  • Mette Tuxen Faber
  • Myassa Kjaerem
  • Cecilie Dovey de la Cour
  • Christian Munk
  • Crispin Kahesa
  • Thomas Iftner
  • Vibeke Rasch
  • Susanne K Kjaer
View graph of relations

OBJECTIVES: Cervical cancer screening by visual inspection with acetic acid (VIA) is a widely used alternative to cytology in developing countries. This study aimed to evaluate risk factors associated with a positive VIA test and with cervical high-grade lesions on cytology.

METHODS: We conducted a large cross-sectional study among 3339 women from urban and rural Tanzania. Study participants were interviewed about socio-demographic, reproductive and lifestyle factors. Blood samples were tested for HIV, and a gynaecological examination was performed. Human papillomavirus (HPV) status was determined by Hybrid Capture 2, and HPV genotyping was done using the LiPA Extra test. We used multivariable logistic regression to estimate adjusted odds ratios (ORs) and confidence intervals (CIs).

RESULTS: The strongest risk factors for VIA positivity were positivity to HIV (OR = 3.48; 95% CI: 2.34-5.17) or to high-risk HPV (HrHPV) (OR = 1.97; 95% CI: 1.37-2.85). HrHPV was by far the strongest predictor of high-grade cytology (OR = 110.1; 95% CI: 50.4-240.4), while there was no significant association with HIV in the multivariable analysis (OR = 1.27; 95% CI: 0.78-2.08). After adjustment for HrHPV, HIV and age, the risk of high-grade cytology also increased with increasing age, number of births and low body mass index (BMI), while high BMI decreased the risk of VIA positivity.

CONCLUSIONS: Infection with HrHPV is a major risk factor for high-grade cytology, while VIA positivity is associated with HIV and to a lesser extent with HrHPV.

Original languageEnglish
JournalTropical medicine & international health : TM & IH
Volume24
Issue number2
Pages (from-to)229-237
Number of pages9
ISSN1360-2276
DOIs
Publication statusPublished - 2019

    Research areas

  • Tanzania, high-grade squamous intraepithelial lesions, human immunodeficiency virus, human papillomavirus, visual inspection with acetic acid, HIV Seropositivity/complications, Multivariate Analysis, Humans, Middle Aged, Young Adult, Acetic Acid, Uterine Cervical Neoplasms/diagnosis, Aged, 80 and over, DNA, Viral/analysis, Adult, Female, Cross-Sectional Studies, Early Detection of Cancer, Risk Factors, Logistic Models, Vaginal Smears, HIV Infections/complications, Adolescent, Cytological Techniques, Papillomaviridae, Aged, Mass Screening/methods

ID: 56088715