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Rigshospitalet - a part of Copenhagen University Hospital
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Expression of the glycolipid globotriaosylceramide (Gb3) in testicular carcinoma in situ

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  1. Methodological approach to Microscopic Colitis diagnosis

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  2. Lymphomas of the head and neck region: an update

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  3. Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands

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  1. Influence of FGF23 and Klotho on male reproduction: Systemic vs direct effects

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  2. WNT signalling in the normal human adult testis and in male germ cell neoplasms

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  3. 'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'

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  4. Distinguishing between hidden testes and anorchia: The role of endocrine evaluation in infancy and childhood

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  5. Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

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Changes in the cell membrane glycolipid composition and metabolism are frequently associated with carcinogenesis. The accumulation of globo-series glycolipids is the most notable change of the germ cell glycolipid composition observed in testicular tumours. In this study, the expression of the globo-series core-structure, globotriaosylceramide (Gb3) was investigated in the preinvasive stage of testicular germ cell tumours, carcinoma in situ (CIS). Seventeen tissue specimens with CIS and 12 samples of overt testicular tumours were immunostained with anti-Gb3 monoclonal antibody 38-13. The accumulation of Gb3 was detected in 12 CIS samples (70.6%) and in 8 invasive tumour samples (66.7%), including seminoma, non-seminoma and a combined germ cell tumour. Our findings indicate that the composition of glycolipids shift at the common preinvasive stage of testicular germ cell tumours and confirm that Gb3 is a tumour-associated antigen of testicular germ cell neoplasia.

Original languageEnglish
JournalVirchows Archiv : an international journal of pathology
Volume426
Issue number4
Pages (from-to)369-74
Number of pages6
ISSN0945-6317
Publication statusPublished - 1995

    Research areas

  • Carcinoma in Situ, Humans, Immunohistochemistry, Male, Testicular Neoplasms, Trihexosylceramides

ID: 44857312