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Rigshospitalet - a part of Copenhagen University Hospital
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Exposure to vitamin D from fortified margarine during fetal life and later risk of pre-eclampsia: the D-tect Study

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  • Maria Stougaard
  • Peter Damm
  • Peder Frederiksen
  • Ramune Jacobsen
  • Berit L Heitmann
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OBJECTIVE: To examine if fetal exposure to a small dosage of extra vitamin D from food fortification was associated with a decrease in the risk of pre-eclampsia later in life.

DESIGN: Cancellation of the mandatory vitamin D fortification of margarine in 1985 created a societal experiment, with entire adjacent birth cohorts exposed or unexposed to extra vitamin D during fetal development. The Danish national medical health registries allowed the identification of pre-eclampsia cases later in life among all exposed and unexposed female individuals.

SETTING: Denmark.

SUBJECTS: Women born between June 1983 and August 1988, who gave birth to their first child at age 14·5-27·5 years (n 32 621).

RESULTS: OR (95 % CI) for pre-eclampsia among women exposed v. unexposed to extra vitamin D from fortification during fetal development was 0·86 (0·76, 0·97). Exposure to extra vitamin D was associated with further reduced odds of pre-eclampsia (0·49 (0·34, 0·72)) among current smokers, but not among former smokers and non-smokers.

CONCLUSIONS: Additional vitamin D in fetal life from food fortification seems to reduce the risk of pre-eclampsia later in life. The risk reduction may be particularly strong among women who smoke during pregnancy.

Original languageEnglish
JournalPublic Health Nutrition
Volume21
Issue number4
Pages (from-to)721-731
Number of pages11
ISSN1368-9800
DOIs
Publication statusPublished - 24 Mar 2018

    Research areas

  • Journal Article

ID: 52746697