Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Exercise Tolerance in Patients Treated With a Durable Left Ventricular Assist Device: Importance of Myocardial Recovery

Research output: Contribution to journalReviewResearchpeer-review

  1. Biomarkers and Their Relation to Cardiac Function Late After Peripartum Cardiomyopathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Dual Vasopressin Receptor Antagonism to Improve Congestion in Patients With Acute Heart Failure: Design of the AVANTI Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device

    Research output: Contribution to journalReviewResearchpeer-review

  4. Pulmonary Arterial Wedge Pressure at Rest and During Exercise in Healthy Adults: A Systematic Review and Meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

The number of patients supported with left ventricular assist devices (LVADs) is growing and support times are increasing. This has led to a greater focus on functional capacity of these patients. LVADs greatly improve heart failure symptoms, but surprisingly, improvement in peak oxygen uptake (pVO2) is small and remains decreased at approximately 50% of normal values. Inadequate increase in cardiac output during exercise is the main responsible factor for the low pVO2 in LVAD recipients. Some patients experience LV recovery during mechanical unloading and these patients have a higher pVO2. Here we review the various components determining exercise cardiac output in LVAD recipients and discuss the potential impact of cardiac recovery on these components. LV recovery may affect several components, leading to improved hemodynamics during exercise and, in turn, physical capacity in patients with advanced heart failure undergoing LVAD implantation.

Original languageEnglish
JournalJournal of Cardiac Failure
Volume27
Issue number4
Pages (from-to)486-493
Number of pages8
ISSN1071-9164
DOIs
Publication statusPublished - Apr 2021

    Research areas

  • Continuous flow left ventricular assist device, exercise, myocardial recovery, work intolerance

ID: 62102160