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Rigshospitalet - a part of Copenhagen University Hospital
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Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients

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DOI

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  4. Report from Eurobiofilms 2011

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  5. Pseudomonas aeruginosa biofilms in cystic fibrosis

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  1. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

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  2. Variant in ERAP1 promoter region is associated with low expression in a patient with a Behçet-like MHC-I-opathy

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  3. Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate

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The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality connected with this disease. The ability of P. aeruginosa to establish chronic infections in CF patients is suggested to be due to the large genetic repertoire of P. aeruginosa and its ability to genetically adapt to the host environment. Here, we review the recent work that has applied whole-genome sequencing to understand P. aeruginosa population genomics, within-host microevolution and diversity, mutational mechanisms, genetic adaptation and transmission events. Finally, we summarize the advances in relation to medical applications and laboratory evolution experiments.

Original languageEnglish
JournalFuture Microbiology
Volume10
Issue number4
Pages (from-to)599-611
Number of pages13
ISSN1746-0913
DOIs
Publication statusPublished - 2015

    Research areas

  • Adaptation, Biological, Cystic Fibrosis, Evolution, Molecular, Genome, Bacterial, Humans, Pseudomonas Infections, Pseudomonas aeruginosa, Respiratory Tract Infections, Sequence Analysis, DNA

ID: 46284366