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Rigshospitalet - a part of Copenhagen University Hospital
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Ergocalciferol treatment and aspects of mineral homeostasis in patients with chronic kidney disease stage 4-5

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  1. Circadian variations in plasma concentrations of cholecystokinin and gastrin in man

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  2. Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

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  3. Platelet function in lung cancer patients undergoing lobectomy

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  4. Platelet increment is not associated with endothelial damage in haematological patients: a prospective observational study

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  1. Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

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  2. Challenges and opportunities for nephrology in Western Europe

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  3. Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

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  4. Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications

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Focus on non-classical effects and possible less side effects of treatment with nutritional vitamin D, raises the expectation of possible benefits from treating chronic kidney disease (CKD) patients with ergocalciferol (vitamin D2). Treatment with 1,25(OH)2 vitamin D (calcitriol) induces elevated fibroblast growth factor 23 (FGF23), while epidemiological studies have found positive effects of nutritional and 25(OH)vitamin D on mortality in CKD. Disturbed mineral homeostasis in CKD is correlated to adverse outcome and cardiovascular mortality. The objective was to examine the possible effects of treatment with high doses of ergocalciferol on parameters of mineral homeostasis in predialysis CKD patients.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume73
Issue number2
Pages (from-to)107-16
Number of pages10
ISSN0036-5513
DOIs
Publication statusPublished - Mar 2013

    Research areas

  • Adult, Bone and Bones, Calcium, Creatinine, Ergocalciferols, Female, Fibroblast Growth Factors, Homeostasis, Humans, Male, Parathyroid Hormone, Phosphates, Renal Insufficiency, Chronic, Treatment Outcome, Vitamins

ID: 42333088