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Rigshospitalet - a part of Copenhagen University Hospital
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Epithelioid hemangioendothelioma in children: The European Pediatric Soft Tissue Sarcoma Study Group experience

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  • Daniel Orbach
  • Max M Van Noesel
  • Bernadette Brennan
  • Nadège Corradini
  • Rita Alaggio
  • Myriam Ben Arush
  • Reineke A Schoot
  • Pablo Berlanga
  • Ilaria Zanetti
  • Lisa Lyngsie Hjalgrim
  • Federica Di Corti
  • Gema Ramirez
  • Michela Casanova
  • Andrea Ferrari
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The European pediatric Soft tissue sarcoma Study Group analyzed all children with epithelioid hemangioendothelioma prospectively registered in the NRSTS-05 (EUDRACT 2005-001139-31) and in MTS-2008 (NCT00379457) studies: 10 patients with localized and one with metastatic disease. Median age was 14.3 years (range, 9.0-18.8). Local therapy was initial primary surgery in seven cases, and five patients received systemic therapy. No patients received radiotherapy. After a median follow-up of 50 months (range, 6-176) for living patients, nine patients remain alive off therapy and two died. Five-year progression free and overall survivals are, respectively, 77.1% (95% confidence interval [CI]: 34.5-93.9) and 74.1% (95% CI: 28.1-93.0).

Original languageEnglish
Article numbere29882
JournalPediatric Blood & Cancer
Volume69
Issue number10
Pages (from-to)e29882
ISSN1545-5009
DOIs
Publication statusPublished - Oct 2022

Bibliographical note

© 2022 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals, Inc.

    Research areas

  • Adolescent, Child, Clinical Studies as Topic, Hemangioendothelioma, Epithelioid/therapy, Humans, Sarcoma/pathology, Soft Tissue Neoplasms/pathology

ID: 79466364