Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Environmental chemicals and thyroid function: an update

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hashimoto's thyroiditis as a risk factor for thyroid cancer

    Research output: Contribution to journalReviewResearchpeer-review

  2. Gut hormones in the treatment of short-bowel syndrome and intestinal failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genetic and environmental origins of hypospadias

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The physiology and timing of male puberty

    Research output: Contribution to journalReviewResearch

  1. Pubarche and Gonadarche Onset and Progression Are Differently Associated With Birth Weight and Infancy Growth Patterns

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Associations between exposure to perfluoroalkyl substances and body fat evaluated by DXA and MRI in 109 adolescent boys

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE OF REVIEW: To overview the effects of endocrine disrupters on thyroid function.

RECENT FINDINGS: Studies in recent years have revealed thyroid-disrupting properties of many environmentally abundant chemicals. Of special concern is the exposure of pregnant women and infants, as thyroid disruption of the developing fetus may have deleterious effects on neurological outcome. Evidence is reviewed for the following groups of chemicals: polychlorinated biphenyls, dioxins, flame retardants, pesticides, perfluorinated chemicals, phthalates, bisphenol A and ultraviolet filters. Chemicals may exert thyroid effects through a variety of mechanisms of action, and some publications have focused on elucidating the mechanisms of specific (groups of) chemicals.

SUMMARY: A large variety of ubiquitous chemicals have been shown to have thyroid-disrupting properties, and the combination of mechanistic, epidemiological and exposure studies indicates that the ubiquitous human and environmental exposure to industrial chemicals may impose a serious threat to human and wildlife thyroid homeostasis. Currently, available evidence suggests that authorities need to regulate exposure to thyroid-disrupting chemicals of pregnant women, neonates and small children in order to avoid potential impairment of brain development. Future studies will indicate whether adults also are at risk of thyroid damage due to these chemicals.

Original languageEnglish
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume16
Issue number5
Pages (from-to)385-91
Number of pages7
ISSN1752-296X
DOIs
Publication statusPublished - Oct 2009

    Research areas

  • Animals, Benzhydryl Compounds, Dioxins, Endocrine Disruptors, Environmental Pollutants, Flame Retardants, Humans, Pesticides, Phenols, Polychlorinated Biphenyls, Sunscreening Agents, Thyroid Gland, Journal Article, Review

ID: 49948351