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Rigshospitalet - a part of Copenhagen University Hospital
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Electrocardiographic features of sarcomere mutation carriers with and without clinically overt hypertrophic cardiomyopathy

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  1. Causes of Mortality in the Marfan Syndrome(from a Nationwide Register Study)

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  2. Usefulness of Transcatheter Aortic Valve Implantation for Treatment of Pure Native Aortic Valve Regurgitation

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  1. Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV

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  2. Aetiologies and temporal trends of atrioventricular block in young patients: a 20-year nationwide study

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  3. Association between Type D personality and outcomes in patients with non-ischemic heart failure

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In hypertrophic cardiomyopathy (HC), electrocardiographic (ECG) changes have been postulated to be an early marker of disease, detectable in sarcomere mutation carriers when left ventricular (LV) wall thickness is still normal. However, the ECG features of mutation carriers have not been fully characterized. Therefore, we systematically analyzed ECGs in a genotyped HC population to characterize ECG findings in mutation carriers (G+) with and without echocardiographic LV hypertrophy (LVH), and to evaluate the accuracy of ECG findings to differentiate at-risk mutation carriers from genetically unaffected relatives during family screening. The ECG and echocardiographic findings were analyzed from 213 genotyped subjects (76 G+/LVH-, 57 G+/LVH+ overt HC, 80 genetically unaffected controls). Cardiac magnetic resonance imaging was available on a subset. Q waves and repolarization abnormalities (QST) were highly specific (98% specificity) markers for LVH- mutation carriers, present in 25% of G+/LVH- subjects, and 3% of controls (p
Original languageEnglish
JournalAmerican Journal of Cardiology
Volume108
Issue number11
Pages (from-to)1606-13
Number of pages8
ISSN0002-9149
DOIs
Publication statusPublished - 2011

    Research areas

  • Adolescent, Adult, Aged, Cardiomyopathy, Hypertrophic, Child, Child, Preschool, Echocardiography, Electrocardiography, Female, Genetic Predisposition to Disease, Heart Ventricles, Heterozygote, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Mutation, Prognosis, Sarcomeres, Young Adult

ID: 33264991