Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Effect of Intermittent versus Continuous Light Exposure on Pupillary Light Response, As Evaluated by Pupillometry

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Editorial: Impact of Traumatic Brain Injuries on Participation in Daily Life and Work: Recent Research and Future Directions

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Measuring Neurobehavioral Disabilities Among Severe Brain Injury Survivors: Reports of Survivors and Proxies in the Chronic Phase

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Optos wide-field imaging versus conventional camera imaging in Danish patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Evaluating an algorithm for screening intervals for diabetic retinopathy and the effect of HbA1c and hypertension

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. Evaluation of a screening algorithm for detection of diabetic retinopathy based on quantitation of retinal pathological elements

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

View graph of relations

Objective: Continuous and intermittent stimuli with green light affect the pupillary light response (PLR) differently. Since the majority of pupillometric studies use blue and red lights, we investigated the effect of continuous and intermittent stimulations on the PLR using red and blue lights.

Methods: Seventeen healthy subjects underwent continuous- and intermittent light stimuli, using red (643 nm) and blue light (463 nm). To avoid the influence of pupil size on the amount of light entering the eye, the procedures were repeated with the stimulus-eye in dilated condition. The maximal pupillary constriction and the early redilation phase of post-illumination pupillary response (PIPREarly) represented the mixed response of melanopsin and rod-cone photoreceptors. The late redilation phase of PIPR (PIPRLate) was the marker of melanopsin-containing retinal ganglion cells.

Results: Intermittent stimuli with blue light elicited significantly larger maximal contraction during dilated condition (P = 0.001), and larger sustained pupillary contraction under dilated as well as undilated condition (P < 0.001) compared to continuous light exposure. Except the PIPREarly during undilated condition, none of the PIPR metrics were significantly different between intermittent and continuous blue light stimuli. Intermittent red light stimuli elicited also a more sustained pupillary contraction regardless of mydriatic instillation (P ≤ 0.02). In addition, intermittent red light exposure resulted in a slightly larger PIPREarly under undilated condition (P = 0.02) and a slightly larger PIPRLate under dilated condition (P = 0.049). Except the PIPRLate to continuous red light stimulus, all PIPR parameters were larger when the light was presented after induction of unilateral mydriasis.

Conclusion: PLR parameters during and after light exposures depend on both the light stimulation mode and the entrance pupillary size.

Original languageEnglish
JournalFrontiers in Neurology
Volume8
Pages (from-to)746
ISSN1664-2295
DOIs
Publication statusPublished - 2018

ID: 56582537