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Rigshospitalet - a part of Copenhagen University Hospital
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Effect of changes in body mass index on the risk of cardiovascular disease and diabetes mellitus in HIV-positive individuals: results from the D: A: D study\

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  1. Incidence of dyslipidemia in people with HIV who are treated with integrase inhibitors versus other antiretroviral agents

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. ABO blood types and sepsis mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Kathy Petoumenos
  • Locadiah Kuwanda
  • Lene Ryom
  • Amanda Mocroft
  • Peter Reiss
  • Stephane De Wit
  • Christian Pradier
  • Andrew Phillips
  • Camilla I Hatleberg
  • Antonella d'Arminio Monforte
  • Rainer Weber
  • Caroline A Sabin
  • Jens Lundgren
  • Matthew G Law
  • D:A:D study group
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BACKGROUND: Weight gain is common among people with HIV once antiretroviral treatment (ART) is commenced. We assess the effect of changes in body mass index (BMI), from different baseline BMI levels, on the risk of cardiovascular disease (CVD) and diabetes mellitus (DM).

METHODS: D:A:D participants receiving ART were followed from their first BMI measurement to the first of either CVD or DM event, or earliest of 1/2/2016 or 6 months after last follow-up. Participants were stratified according to their baseline BMI, and changes from baseline BMI were calculated for each participant. Poisson regression models were used to assess the effects of changes on BMI on CVD or DM events.

RESULTS: There were 2,104 CVD and 1,583 DM events over 365,287 and 354,898 person years (rate: CVD 5.8/1000 (95% CI 5.5-6.0); DM 4.5/1000 (95% CI 4.2 - 4.7)). Participants were largely male (74%), baseline mean age of 40 years and median BMI of 23.0 (IQR: 21.0-25.3). Risk of CVD by change in BMI from baseline, stratified by baseline BMI strata showed little evidence of an increased risk of CVD with an increased BMI in any baseline BMI strata. An increase in BMI was associated with an increased risk of DM across all baseline BMI strata.

CONCLUSIONS: While increases in BMI across all levels of baseline BMI were not associated with an increased risk of CVD, such changes were consistently associated with increased risk of DM. There was also some evidence of an increased risk of CVD with a decrease in BMI.

Original languageEnglish
JournalJournal of acquired immune deficiency syndromes (1999)
Volume86
Issue number5
Pages (from-to)579-586
Number of pages8
ISSN1525-4135
DOIs
Publication statusPublished - 15 Apr 2021

ID: 61633484