Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Early life body size, growth and risks of systemic lupus erythematosus - A large Danish observational cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Defining the optimal biological monotherapy in rheumatoid arthritis: A systematic review and meta-analysis of randomised trials

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Proceedings from The 8th Annual International Society for Musculoskeletal Imaging in Rheumatology (ISEMIR) Conference

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Doppler Ultrasound Predicts Successful Discontinuation of Biological DMARDs in Rheumatoid Arthritis Patients in Sustained Clinical Remission

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  3. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Peter E Thomas
  • Britt W Jensen
  • Kathrine K Sørensen
  • Søren Jacobsen
  • Julie Aarestrup
  • Jennifer L Baker
View graph of relations

OBJECTIVES: Adult obesity may increase the risks of systemic lupus erythematosus (SLE), and there are genetic links between adult height and SLE. Thus, it is plausible that size earlier in life may be important in the aetiology of SLE as well. We investigated whether birthweight, childhood body mass index (BMI; [kg/m2]), height and growth are associated with risks of adult SLE.

METHODS: The study included 346,627 children from the Copenhagen School Health Records Register, born 1930-1996 with measured weights and heights from 7-13 years. Birthweight information was available from 1936. Linkages were made to the Danish National Patient Register for information on registrations of SLE. During follow-up, 435 individuals (366 women) were registered with SLE. Cox proportional hazards regressions were performed to estimate hazard ratios (HR) and 95% confidence intervals (CI).

RESULTS: No differences by sex were detected in any of the associations. Birthweight was not associated with SLE risks. Childhood BMI and height were positively and linearly associated with SLE risks. For BMI at age 7, the HR was 1.11 (95% CI: 1.01-1.23) per z-score. For height at age 7, the HR was 1.13 (95% CI: 1.02-1.24) per z-score. The estimates were similar in magnitude across all childhood ages for BMI and height. There were limited indications that change in BMI or growth in height during childhood influence the risks of SLE in adulthood.

CONCLUSIONS: Childhood body size is associated with risks of adult SLE, which supports the hypothesis that early life factors are important in SLE aetiology.

Original languageEnglish
JournalSeminars in Arthritis and Rheumatism
Volume50
Issue number6
Pages (from-to)1507-1512
Number of pages6
ISSN0049-0172
DOIs
Publication statusPublished - Dec 2020

    Research areas

  • Birthweight, Body weights and measures, Child, Growth and development, Obesity, Systemic lupus erythematosus

ID: 59633090