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Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

Early indicators of primary brain tumors: a population-based study with ten years follow-up

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

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  • Mirketa Marku
  • Birthe Krogh Rasmussen
  • Susanne Oksbjerg Dalton
  • Christoffer Johansen
  • Petra Hamerlik
  • Klaus Kaae Andersen
  • Sandra Melanie Meier
  • Pernille Envold Bidstrup
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BACKGROUND AND PURPOSE: To improve diagnoses of primary brain tumors, knowledge about early indicators is needed. We used nationwide Danish health registries to conduct a population-based case-control study including all persons diagnosed with a primary brain tumor between 2005-2014 in Denmark.

METHODS: All 5,135 adults diagnosed with a primary brain tumor in the Danish Cancer Registry were matched to 19,572 general population comparisons from the Danish Civil Registration System. We applied conditional logistic regression analyses to estimate age- and multivariable-adjusted odds ratios (ORs) for the occurrence of a primary brain tumor up to ten years after hospital diagnoses or prescription of medications related to nervous system diseases and mental and behavioral disorders.

RESULTS: We found increased odds for primary brain tumor after nervous system diseases and mental and behavioral disorders manifested up to ten years before tumor diagnosis. Increased odds were seen especially for hospital contacts for inflammatory nervous system diseases (OR 11.3; 95% CI, 6.5-19.7), epilepsy (OR 9.0; 95% CI, 7.6-10.7) and antiepileptic medications (OR 3.6; 95% CI, 3.2-4.0), while anti-dementia medications provided a strong, protective association for primary brain tumors (OR 0.5; 95% CI, 0.3-0.8).

CONCLUSIONS: Sub-groups of patients diagnosed with or being prescribed certain medications targeting nervous system diseases and mental and behavioral disorders may be at increased risk of being diagnosed with a primary brain tumor. Further studies should disentangle potential underlying common pathogenetic pathways. The results are important for the development of systematic clinical approaches to ensure early diagnosis of primary brain tumors.

Original languageEnglish
JournalEuropean Journal of Neurology
ISSN1351-5101
DOIs
Publication statusE-pub ahead of print - 11 Sep 2020

    Research areas

  • adult, case–control study, oncology, primary brain tumour, risk factors

ID: 60964639