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Rigshospitalet - a part of Copenhagen University Hospital
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Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke

Research output: Contribution to journalJournal articleResearchpeer-review

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  4. Local complement activation is associated with primary graft dysfunction after lung transplantation

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  5. Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I

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  • R Zangari
  • E R Zanier
  • G Torgano
  • A Bersano
  • S Beretta
  • E Beghi
  • B Casolla
  • N Checcarelli
  • S Lanfranconi
  • A Maino
  • C Mandelli
  • G Micieli
  • F Orzi
  • E Picetti
  • M Silvestrini
  • N Stocchetti
  • B Zecca
  • P Garred
  • M G De Simoni
  • LEPAS group
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BACKGROUND: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.

METHODS: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS).

RESULTS: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p < 0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p < 0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p < 0.001 and <0.05, respectively). For MBL no difference was detected between patients and controls or within patients at the different time points. In multivariate analysis, early ficolin-1 was independently associated with unfavorable mRS outcome (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 % 1.11-4.39, p = 0.023). Early ficolin-1 improved the discriminating ability of an outcome model including NIHSS and age (area under the curve (AUC) 0.95, CI 95 % 0.90-0.99, p = 0.0001).

CONCLUSIONS: The ficolins are consumed within 6 h after stroke implicating activation of the LP. Early ficolin-1 is selectively related to 3-month unfavorable outcome.

Original languageEnglish
JournalJournal of Neuroinflammation
Volume13
Pages (from-to)16
ISSN1742-2094
DOIs
Publication statusPublished - 2016

    Research areas

  • Journal Article, Research Support, Non-U.S. Gov't

ID: 48989760