Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Dynamic Changes in LH/FSH Ratios in Infants with Normal Sex Development

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Cardiovascular risk in Danish transgender persons: a matched historical cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pituitary function and the response to GH therapy in patients with Langerhans Cell Histiocytosis: Analysis of the KIMS Database

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Randomized Controlled Trial of Tesomet for Weight Loss in Hypothalamic Obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Increased liver fat associates with severe metabolic perturbations in low birth weight men

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Objective: Little is known about the ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) during infancy. This study aimed to evaluate serum and urinary LH/FSH as a marker of sex with age-specific cutoffs in healthy infants.

Design: A prospective, longitudinal cohort study of healthy infants aged 0-1.2 years.

Methods: In total, 236 healthy infants (122 boys and 114 girls) from The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), with 567 serum and 603 urine samples, were included. Measures of diagnostic accuracy, including sensitivity and specificity, were used to assess the ability of LH/FSH to detect sex in healthy infants.

Results: In both serum and urine, LH/FSH was highest in males with minimal overlap between the sexes. In contrast to isolated LH and FSH concentrations, LH/FSH ratios in both serum and urine were excellent markers of sex from 0 to 1.2 years with median sensitivities and specificities ranging from 93 to 100% with correspondingly narrow 95% CIs.

Conclusions: Serum and urinary LH/FSH ratios are excellent discriminators of sex in healthy infants during the entire first year of life. The clinical role and application of the ratio remain to be elucidated.

Original languageEnglish
JournalEuropean Journal of Endocrinology
Volume187
Issue number1
Pages (from-to)135-142
Number of pages8
ISSN0804-4643
DOIs
Publication statusPublished - 1 Jun 2022

ID: 77926868