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Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure

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Harvard

Joseph, G, Marott, JL, Torp-Pedersen, C, Biering-Sørensen, T, Nielsen, G, Christensen, A-E, Johansen, MB, Schnohr, P, Sogaard, P & Mogelvang, R 2019, 'Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure' Hypertension, vol. 74, no. 6, pp. 1307-1315. https://doi.org/10.1161/HYPERTENSIONAHA.119.13786

APA

CBE

Joseph G, Marott JL, Torp-Pedersen C, Biering-Sørensen T, Nielsen G, Christensen A-E, Johansen MB, Schnohr P, Sogaard P, Mogelvang R. 2019. Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure. Hypertension. 74(6):1307-1315. https://doi.org/10.1161/HYPERTENSIONAHA.119.13786

MLA

Vancouver

Author

Joseph, Gowsini ; Marott, Jacob Louis ; Torp-Pedersen, Christian ; Biering-Sørensen, Tor ; Nielsen, Gitte ; Christensen, Ann-Eva ; Johansen, Martin Berg ; Schnohr, Peter ; Sogaard, Peter ; Mogelvang, Rasmus. / Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure. In: Hypertension. 2019 ; Vol. 74, No. 6. pp. 1307-1315.

Bibtex

@article{a6e3b9712ddb4748b01e2470fa01ca47,
title = "Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure",
abstract = "It has been a challenge to verify the dose of exercise that will produce the maximum health benefits in hypertension. This study aimed to explore the association between level of daily physical activity, all-cause mortality and cardiovascular outcome at different blood pressure levels. A random sample of 18 974 white men and women aged 20 to 98 years were examined in a prospective cardiovascular population study. Self-reported activity level in leisure-time was drawn from the Physical Activity Questionnaire (level I: inactivity; II: light activity; and III: moderate/high-level activity). Blood pressure was defined as normal blood pressure: <120/<80 mm Hg; Prehypertension: 120-139/80-89 mm Hg; Stage I hypertension: 140-159/90-99 mm Hg; Stage II hypertension ≥160/≥100 mm Hg. The mean follow-up time was 23.4±11.7 years. At all levels of blood pressure, higher levels of physical activity were associated with lower all-cause mortality in a dose-response pattern. The pattern remained unchanged after adjustment for following confounders: sex, age, smoking status, education, diabetes mellitus, previous cardiovascular disease, body mass index, and calendar time. Compared with inactivity, following hazard ratios were found for stage I hypertension: light activity, hazard ratio 0.78 (0.72-0.84; P<0.001), moderate/high-level activity, hazard ratio 0.69 (0.63-0.75; P<0.001). At all levels of blood pressure, the risk of cardiovascular events was significantly reduced independent of the level of physical activity. In conclusion, the association between physical activity and all-cause mortality was present in an inverse dose-response pattern at all levels of blood pressure. Physical activity was associated with reduction in cardiovascular events independent of the level of physical activity.",
author = "Gowsini Joseph and Marott, {Jacob Louis} and Christian Torp-Pedersen and Tor Biering-S{\o}rensen and Gitte Nielsen and Ann-Eva Christensen and Johansen, {Martin Berg} and Peter Schnohr and Peter Sogaard and Rasmus Mogelvang",
year = "2019",
month = "12",
doi = "10.1161/HYPERTENSIONAHA.119.13786",
language = "English",
volume = "74",
pages = "1307--1315",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams & Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure

AU - Joseph, Gowsini

AU - Marott, Jacob Louis

AU - Torp-Pedersen, Christian

AU - Biering-Sørensen, Tor

AU - Nielsen, Gitte

AU - Christensen, Ann-Eva

AU - Johansen, Martin Berg

AU - Schnohr, Peter

AU - Sogaard, Peter

AU - Mogelvang, Rasmus

PY - 2019/12

Y1 - 2019/12

N2 - It has been a challenge to verify the dose of exercise that will produce the maximum health benefits in hypertension. This study aimed to explore the association between level of daily physical activity, all-cause mortality and cardiovascular outcome at different blood pressure levels. A random sample of 18 974 white men and women aged 20 to 98 years were examined in a prospective cardiovascular population study. Self-reported activity level in leisure-time was drawn from the Physical Activity Questionnaire (level I: inactivity; II: light activity; and III: moderate/high-level activity). Blood pressure was defined as normal blood pressure: <120/<80 mm Hg; Prehypertension: 120-139/80-89 mm Hg; Stage I hypertension: 140-159/90-99 mm Hg; Stage II hypertension ≥160/≥100 mm Hg. The mean follow-up time was 23.4±11.7 years. At all levels of blood pressure, higher levels of physical activity were associated with lower all-cause mortality in a dose-response pattern. The pattern remained unchanged after adjustment for following confounders: sex, age, smoking status, education, diabetes mellitus, previous cardiovascular disease, body mass index, and calendar time. Compared with inactivity, following hazard ratios were found for stage I hypertension: light activity, hazard ratio 0.78 (0.72-0.84; P<0.001), moderate/high-level activity, hazard ratio 0.69 (0.63-0.75; P<0.001). At all levels of blood pressure, the risk of cardiovascular events was significantly reduced independent of the level of physical activity. In conclusion, the association between physical activity and all-cause mortality was present in an inverse dose-response pattern at all levels of blood pressure. Physical activity was associated with reduction in cardiovascular events independent of the level of physical activity.

AB - It has been a challenge to verify the dose of exercise that will produce the maximum health benefits in hypertension. This study aimed to explore the association between level of daily physical activity, all-cause mortality and cardiovascular outcome at different blood pressure levels. A random sample of 18 974 white men and women aged 20 to 98 years were examined in a prospective cardiovascular population study. Self-reported activity level in leisure-time was drawn from the Physical Activity Questionnaire (level I: inactivity; II: light activity; and III: moderate/high-level activity). Blood pressure was defined as normal blood pressure: <120/<80 mm Hg; Prehypertension: 120-139/80-89 mm Hg; Stage I hypertension: 140-159/90-99 mm Hg; Stage II hypertension ≥160/≥100 mm Hg. The mean follow-up time was 23.4±11.7 years. At all levels of blood pressure, higher levels of physical activity were associated with lower all-cause mortality in a dose-response pattern. The pattern remained unchanged after adjustment for following confounders: sex, age, smoking status, education, diabetes mellitus, previous cardiovascular disease, body mass index, and calendar time. Compared with inactivity, following hazard ratios were found for stage I hypertension: light activity, hazard ratio 0.78 (0.72-0.84; P<0.001), moderate/high-level activity, hazard ratio 0.69 (0.63-0.75; P<0.001). At all levels of blood pressure, the risk of cardiovascular events was significantly reduced independent of the level of physical activity. In conclusion, the association between physical activity and all-cause mortality was present in an inverse dose-response pattern at all levels of blood pressure. Physical activity was associated with reduction in cardiovascular events independent of the level of physical activity.

U2 - 10.1161/HYPERTENSIONAHA.119.13786

DO - 10.1161/HYPERTENSIONAHA.119.13786

M3 - Journal article

VL - 74

SP - 1307

EP - 1315

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 6

ER -

ID: 58139632