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Do patients with prostate cancer benefit from exercise interventions? a systematic review and meta-analysis

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Men diagnosed and treated for prostate cancer experience severe adverse effects on quality of life (QoL) and metabolic health, some of which may be preventable or reversible with exercise, the benefits of which healthcare providers and patients increasingly acknowledge, though existing evidence on its effects varies in significance and magnitude. We aimed to review the effect of exercise on QoL and metabolic health in a broad prostate cancer population. A systematic search was conducted in nine databases and eligible trials were included in the meta-analytic procedure. All outcomes were stratified into aerobic exercise, resistance exercise, and a combination of both. The review identified 33 randomised controlled trials (2567 participants) eligible for inclusion. Exercise had a borderline small positive effect on cancer-specific QoL (standardised mean difference (SMD) = 0.10, 95% confidence interval (CI) -0.01-0.22), and a moderate to large effect on cardiovascular fitness (SMD = 0.46, 95% CI 0.34-0.59) with aerobic exercise being the superior modality (SMD = 0.60, 95% CI 0.29-0.90). A positive significant effect was seen in lower body strength, whole-body fat mass, general mental health, and blood pressure. No significant effect was seen in fatigue, lean body mass, and general physical health. We thereby conclude that exercise is effective in improving metabolic health in men diagnosed with prostate cancer, with aerobic exercise as the superior modality. The effect of exercise on QoL was small and not mediated by choice of exercise modality.
Original languageEnglish
Article number972
JournalInternational Journal of Environmental Research and Public Health
Issue number2
Pages (from-to)1-23
Number of pages23
Publication statusPublished - 15 Jan 2022

Bibliographical note

1660-4601 Andersen, Martin Færch Orcid: 0000-0003-0469-7557 Midtgaard, Julie Bjerre, Eik Dybboe Journal Article Review Switzerland Int J Environ Res Public Health. 2022 Jan 15;19(2):972. doi: 10.3390/ijerph19020972.

    Research areas

  • exercise frailty health metabolic health older adults prostate cancer quality of life, Exercise, Health, Metabolic health, Frailty, Older adults, Prostate cancer, Quality of life

ID: 72735679