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Rigshospitalet - a part of Copenhagen University Hospital
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DNA Methyltransferase Inhibitors in Myeloid Cancer: Clonal Eradication or Clonal Differentiation?

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Improvements in Imaging of Hodgkin Lymphoma: Positron Emission Tomography

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Radiotherapy for Hodgkin Lymphoma: Reducing Toxicity While Maintaining Efficacy

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  3. Effects of exercise on tumor physiology and metabolism

    Research output: Contribution to journalReviewResearchpeer-review

  1. KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Epigenetic therapy in hematological cancers

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  3. Blodsygdomme

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

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DNA methyltransferase inhibitors, so-called hypomethylating agents (HMAs), are the only drugs approved for the treatment of higher-risk myelodysplastic syndromes and are widely used in this context. However, it is still unclear why some patients respond to HMAs, whereas others do not. Recent sequencing efforts have identified molecular disease entities that may be specifically sensitive to these drugs, and many attempts are being made to clarify how HMAs affect the malignant clone during treatment. Here, we review the most recent data on the clinical effects of HMAs in myeloid malignancies.

Original languageEnglish
JournalCancer Journal
Volume23
Issue number5
Pages (from-to)277-285
Number of pages9
ISSN1528-9117
DOIs
Publication statusPublished - 1 Sep 2017

    Research areas

  • Journal Article

ID: 52056014