Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Disturbances of consciousness and sleep-wake functions in patients following brainstem lesions

Research output: Contribution to journalConference abstract in journalResearchpeer-review

  1. More precise phenotyping of cluster headache using prospective attack reports

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Randomized trial of facilitated subcutaneous immunoglobulin in multifocal motor neuropathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Acute endovascular reperfusion treatment in patients with ischaemic stroke and large-vessel occlusion (Denmark 2011–2017)

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. European Academy of Neurology guideline on trigeminal neuralgia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The role of sleep in the pathophysiology of nocturnal enuresis

    Research output: Contribution to journalReviewResearchpeer-review

  3. CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. External validation of a data-driven algorithm for muscular activity identification during sleep

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Rapid eye movements are reduced in blind individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Abstract: Sleep-wake and circadian rhythmicity including several vital functions are regulation by complex interplay between basic structures in the brain: brain stem, thalamus, hypothalamus and basic forebrain. Discrete but interconnected clusters of cells located within the brainstem and hypothalamus comprise the circuits that generate wakefulness, non-rapid eye movement (non-REM) sleep, and REM sleep. The hypocretin system plays a function for wake and REM/NREM regulation including reticular activating system (RAS) projects to brain regions via complex projections via thalamus and forebrain. The circadian system involves suprachiasmatic nucleus (SCN) in the hypothalamic region with projections to several system, including a complex cervical parthway to the pineal gland secreting melatonin. As such several lesions may cause disturbances in these regulatory functions. Examples includes specific lesion in inferior hypothalamic region which may involve SCN (circadian disturbances), the ventrolateral preoptic nucleus or its projections (loss of sleep regulation), bi-thalamic lesions (somnolence), to pontine region (REM regulation disturbances), sublaterodorsal nucleus (REM sleep Behavior Disorder), to the hypocretinergic system (narcolepsy with cataplexy), cervical lesion or pineal gland (abolished melatonin secretion). Such lesions may include neurodegeneration (alpha-synucleinopathies, tauopathies), stroke, tumors, inflammations including autoimmune involvement. Disclosure: Nothing to disclose.
Original languageEnglish
Article numberFW10_3
JournalEuropean Journal of Neurology
Volume26
Issue numberSuppl. 1
Pages (from-to)976
Number of pages1
ISSN1351-5101
Publication statusPublished - 2019

ID: 59222234