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Rigshospitalet - a part of Copenhagen University Hospital
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Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia

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The distribution of mRNA for pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 (PAC1) and vasoactive intestinal polypeptide (VIP) types 1 and 2 (VPAC1 and VPAC2, respectively) receptors was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in human cerebral arteries and in trigeminal, otic, sphenopalatine and superior cervical ganglia. RT-PCR products of the expected sizes were detected in the arteries, in both the presence and absence of endothelium. In the majority (80%) of the trigeminal, otic and superior cervical ganglia, mRNA for all three receptors were found (n = 5). However, in the sphenopalatine ganglion neither VPAC2 nor PAC1 was detected (n = 2). This finding indicates the occurrence of both prejunctional (ganglia) and postjunctional (vessels) location of VIP and PACAP receptors.

Original languageEnglish
JournalNeuroReport
Volume13
Issue number4
Pages (from-to)507-9
Number of pages3
ISSN0959-4965
Publication statusPublished - 25 Mar 2002
Externally publishedYes

    Research areas

  • Adult, Cerebral Arteries, Endothelium, Vascular, Humans, RNA, Messenger, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I, Receptors, Pituitary Hormone, Receptors, Vasoactive Intestinal Peptide, Receptors, Vasoactive Intestinal Peptide, Type II, Receptors, Vasoactive Intestinal Polypeptide, Type I, Superior Cervical Ganglion, Trigeminal Ganglion

ID: 44909097