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Distribution of CGRP and CGRP receptor components in the rat brain

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  1. Letter to the editor regarding "Have you ever experienced a headache of any kind?"

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  2. Vancouver Declaration II on Global Headache Patient Advocacy 2019

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  3. Low frequency activation of the sphenopalatine ganglion does not induce migraine-like attacks in migraine patients

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  4. No central action of CGRP antagonising drugs in the GTN mouse model of migraine

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  1. Vancouver Declaration II on Global Headache Patient Advocacy 2019

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion

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  3. CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles

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  4. Cellular distribution of PACAP-38 and PACAP receptors in the rat brain: Relation to migraine activated regions

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Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of calcitonin gene-related peptide, receptor activity-modifying protein 1 and calcitonin receptor-like receptor in the rat brain in a region of 0.5-1.5 mm lateral to the midline. We found calcitonin gene-related peptide immunoreactivity in most of the neurons of the cerebral cortex, hippocampus, cerebellum, thalamic nuclei, hypothalamic nuclei and brainstem nuclei. In contrast, receptor activity-modifying protein 1 and calcitonin receptor-like receptor immunoreactivity were found almost exclusively in the neuronal processes in the investigated regions. Conclusion Overall, the degree of expression of calcitonin gene-related peptide and calcitonin gene-related peptide receptor components in the central nervous system is astonishingly complex and suggestive of many different brain functions, including a possible role in migraine. However, currently, the presence of calcitonin gene-related peptide and the nature of its receptors throughout the brain is an enigma yet to be solved.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume39
Issue number3
Pages (from-to)342-353
Number of pages12
ISSN0333-1024
DOIs
Publication statusPublished - 2019

    Research areas

  • CGRP, Migraine, RAMP1/CLR, immunohistochemistry, rat brain

ID: 51751252