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Rigshospitalet - a part of Copenhagen University Hospital
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Disseminated fusariosis with cerebral involvement in a patient with acute myeloid leukemia: Successful outcome with intrathecal -and systemic antifungal treatment

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The outcome of invasive fusariosis in hematological patients is usually dismal, particularly in patients with persistent neutropenia. We report a patient with acute myeloid leukemia (AML) with Fusarium dimerum sinusitis with hematogenic dissemination to the brain. Despite surgical debridements of the sinuses and liposomal amphotericin B, voriconazole and terbinafine, there was progression with cerebral involvement after recovery of neutropenia and with detection of F. dimerum in the cerebrospinal fluid. Topical antifungal treatment with amphotericin B deoxycholate (deoxy-AMB) intrathecally was initiated with administration three times a week. After 99 treatments of intrathecal deoxy-AMB, she had regression of the fusarium CNS lesions and is currently in complete remission from AML. This report supports the use of intrathecal amphotericin B for treatment of CNS fusariosis.

Original languageEnglish
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Volume28
Issue number9
Pages (from-to)1324-1328
Number of pages5
ISSN1341-321X
DOIs
Publication statusPublished - Sep 2022

Bibliographical note

Copyright © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

    Research areas

  • Antifungal Agents/therapeutic use, Female, Fusariosis/diagnosis, Fusarium, Humans, Leukemia, Myeloid, Acute/complications, Neutropenia/drug therapy, Voriconazole/therapeutic use, Amphotericin B, Voriconazole, Intrathecal treatment, Acute myeloid leukemia

ID: 79118571