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Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

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  • Christina Sølund
  • Sofie Hallager
  • Martin S. Pedersen
  • Ulrik Fahnøe
  • Anja Ernst
  • Henrik B. Krarup
  • Birgit T. Røge
  • Peer B. Christensen
  • Alex L. Laursen
  • Jan Gerstoft
  • Erika Bélard
  • Lone G. Madsen
  • Kristian Schønning
  • Anders G. Pedersen
  • Jens Bukh
  • Nina Weis
  • The DANHEP Group
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AbstractObjectives: We describe factors associated with and barriers to initiation of Direct Acting Antiviral (DAA) treatment in patients with chronic hepatitis C, who fulfill national fibrosis treatment guidelines in Denmark.Materials and Methods: In this nationwide cohort study, we included patients with chronic hepatitis C from The Danish Database for Hepatitis B and C (DANHEP) who fulfilled fibrosis treatment criteria. Factors associated with treatment initiation and treatment failure were determined by logistic regression analyses. Medical records were reviewed from patients who fulfilled fibrosis treatment criteria, but did not initiate DAA treatment to determine the cause.Results: In 344 (49%) of 700 patients, who fulfilled treatment criteria, factors associated with DAA treatment initiation were transmission by other routes than injecting drug use odds ratio (OR) 2.13 (CI: 1.38–3.28), previous treatment failure OR 2.58 (CI: 1.84–3.61) and ALT above upper limit of normal OR 1.60 (CI: 1.18–2.17). Th...
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume53
Issue number7
Pages (from-to)849-856
ISSN0036-5521
DOIs
Publication statusPublished - 1 May 2018

ID: 54945681