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Rigshospitalet - a part of Copenhagen University Hospital
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Differences in gene expression despite identical histomorphology in sinonasal intestinal type adenocarcinoma and metastases from colorectal adenocarcinoma

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Sinonasal intestinal-type adenocarcinoma (sITAC) is histomorphologically indistinguishable from colorectal adenocarcinoma (CRC) leading to diagnostic challenges. Metastases from CRCs to the sinonasal tract have been reported. The aim of the study was to identify a biomarker making it possible to distinguish between sITAC and metastases of colorectal origin. Formalin-fixated paraffin-embedded (FFPE) tissue from 20 consecutive patients with sITAC treated at Rigshospitalet, Denmark from 2005 to 2017, 20 patients with CRC, and second patients with both sinonasal and colorectal carcinomas were included, and RNA-sequencing was performed on all samples. Moreover, a series of 26 samples from metastasizing CRC were included (in-house data). 3139 differentially expressed genes were identified, of these several were deemed as possible biomarkers, including CSDE1, for which immunohistochemical staining was performed. sITAC and CRC differ in genomic expression. CSDE1, previously found upregulated in CRC, was significantly differentially expressed. Using immunohistochemical staining, no sITACs displayed strong and diffuse staining for CSDE1, which represents a potential marker to use in distinguishing sITAC from a metastasis of colorectal origin. This knowledge could improve the diagnostic process and hopefully the outcome in patients with this rare tumor.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume130
Issue number9
Pages (from-to)551-559
Number of pages9
ISSN0903-4641
DOIs
Publication statusPublished - Sep 2022

Bibliographical note

This article is protected by copyright. All rights reserved.

    Research areas

  • Adenocarcinoma/pathology, Biomarkers, Tumor/genetics, Colorectal Neoplasms/pathology, Gene Expression, Humans, intestinal-type adenocarcinoma, carcinoma, genomics, Sinonasal, cancer

ID: 78825266