Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Differences and Temporal Changes in Risk of Invasive Pneumococcal Disease in Adults with Hematological Malignancies: Results from a Nationwide 16-Year Cohort Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Estimation of SARS-CoV-2 infection fatality rate by real-time antibody screening of blood donors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Risk factors and Predictors of Mortality in Streptococcal Necrotizing Soft-Tissue Infections: A Multicenter Prospective Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hepatic steatosis associated with exposure to elvitegravir and raltegravir

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Venous thromboembolism and major bleeding in patients with COVID-19: A nationwide population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Abnormal eosinophil count at CLL diagnosis correlates with shorter treatment free survival

    Research output: Contribution to journalLetterpeer-review

  4. First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Venous thromboembolism and major bleeding in patients with COVID-19: A nationwide population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Patients with hematological malignancies (HM) are known to carry an increased risk of invasive pneumococcal disease (IPD). However, temporal variations in IPD risks following a cancer diagnosis remain poorly characterized. To inform vaccine guidelines and patient management, we assessed the IPD incidence among patients with HM and other malignancies.

METHODS: The study population included all individuals aged ≥15 years during 2000-2016 in Denmark. Variations in incidences of IPD over time and between different types of hematological malignancies and diagnoses were assessed by Poisson regression.

RESULTS: During 85 002 224 person-years of observation, 13 332 episodes of a first IPD were observed, of which 765 (5.7%) occurred among individuals with HM. Among HM patients, the IPD incidence rate decreased continuously during the study period (rate ratio per year, 0.91; 95% confidence interval, .90-.92). The risk of IPD in patients with HM was up to 39 times higher when compared to the background population and was highest for multiple myeloma, acute lymphoblastic leukemia, and chronic lymphocytic leukemia. Unlike other malignancies, the increased IPD risk did not wane with the time since HM diagnosis. We found a vaccination uptake of only ≤2% in patients with HM and ≤1% for those with other types of malignancies.

CONCLUSIONS: Adults with HM in general and patients with lymphoid malignancies in particular have an increased risk for IPD, compared with patients with other types of cancer and with individuals free of cancer. The pneumococcal vaccination uptake is extremely low in this at risk-population. Efforts to prevent IPD in HM patients are continuously warranted.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume72
Issue number3
Pages (from-to)463-471
Number of pages9
ISSN1058-4838
DOIs
Publication statusPublished - 1 Feb 2021

ID: 60284986