Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prognostic factors for relapse in patients with clinical stage I testicular cancer: Protocol for a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Change in mammographic density across birth cohorts of Dutch breast cancer screening participants

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Optimized Biobanking Procedures for Preservation of RNA in Tissue: Comparison of Snap-Freezing and RNAlater-Fixation Methods

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Mammographic Density and Screening Sensitivity, Breast Cancer Incidence and Associated Risk Factors in Danish Breast Cancer Screening

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation. The patient material consisted of 260 patients, all with a preoperative diagnosis of a papillomatous process in core biopsy. The lesion was excised, and 71% had a benign lesion. The rest had lesions ranging from premalignant to malignant. In the clinical, radiological and histopathological investigations conducted, we were not able to identify factors that statistically significant could predict whether the lesion was benign or malignant. However, our data showed a higher prevalence of malignant and premalignant lesions for older patient, larger lesions, and lesions found at a longer distance from the papilla. We conclude that, since almost 30% of the patients in our study ended up with a premalignant or malignant diagnosis, where no statistically significant preoperative factors could indicate a benign outcome, operation is warranted in all patients with a preoperative diagnosis of a papillomatous lesion.

Original languageEnglish
JournalBreast (Edinburgh, Scotland)
Volume40
Pages (from-to)177-180
Number of pages4
ISSN0960-9776
DOIs
Publication statusPublished - Aug 2018

ID: 55235665