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Rigshospitalet - a part of Copenhagen University Hospital
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Development of depression in patients with oral cavity cancer: a systematic review

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BACKGROUND: The incidence of oral cancer is approximately 300,000 patients annually. A cancer diagnosis and treatment affect both physical and mental issues.

OBJECTIVES: The aim of this systematic review was to examine the development of depression in patients who have been treated for oral squamous cell carcinoma (OSCC).

MATERIAL AND METHODS: PubMed and EMBASE were systematically searched for studies addressing depression among patients treated for OSCC and published within the past ten years.

RESULTS: We identified three studies comprising 528 patients (range: 75-349), primarily men (66-83%), treated for OSCC from Europe and India. Tumour stage, treatment modality, and scales used to evaluate depressive symptoms varied in the studies. The European studies showed that 28% of the patients experienced depressive symptoms on the Hospital Anxiety and Depression Scale (HADS) and a mean of 8.0 on depression in the Brief Symptom Inventory (BSI). The Indian study showed a significant increase (p Value < .001) from moderate to severe depressive symptoms on the Depression, Anxiety, and Stress Scale-21 (DASS-21). Conclusion and Significance: This systematic review showed that OSCC patients are at risk of developing depressive symptoms after treatment, though severity of symptoms varied. This knowledge could preferably be implemented in future follow-up regimes.

Original languageEnglish
JournalActa Oto-Laryngologica
Volume140
Issue number10
Pages (from-to)876-881
Number of pages6
ISSN0001-6489
DOIs
Publication statusPublished - Oct 2020

    Research areas

  • after treatment, depression, depressive symptoms, oral cavity cancer, oral squamous cell carcinoma, OSCC, Systematic review

ID: 60536536