Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Delayed two-stage breast reconstruction: The impact of radiotherapy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Efficacy of breast reconstruction with fat grafting: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  1. Dexamethasone Dose and Early Postoperative Recovery after Mastectomy: A Double-blind, Randomized Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The role of H1 antihistamines in contralateral breast cancer: a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Enhanced Recovery After Head and Neck Cancer Reconstruction With a Free Flap-What Is Next?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hvor bevæger forskningen i behandlingen af cancer sig hen?

    Research output: Contribution to journalJournal articleResearch

View graph of relations

BACKGROUND: Despite a trend towards immediate breast reconstruction in recent years, delayed breast reconstruction using a tissue expander remains a common procedure. Radiotherapy after mastectomy but before reconstruction is a risk factor, although studies examining the effect of this are limited. The aim of this retrospective cohort study is to evaluate the impact of pre-reconstructive radiotherapy (PRT) in patients undergoing breast reconstruction using an expander/implant.

MATERIALS AND METHODS: Two hundred twenty-three consecutive patients underwent unilateral mastectomy followed by expander-based reconstruction over a 10-year period (2004-2013). Fifty patients (22%) received radiotherapy before reconstruction (PRT group), and 173 patients (78%) did not (non-PRT group). Descriptive patient data as well as data regarding the operations, hospitalisation and complications were collected. Statistical analyses such as logistic regression, Fisher exact test and multivariate analysis were performed using R-statistics.

RESULTS: PRT was a significant predictor of loss of reconstruction, and when adjusted for smoking and body mass index (BMI), it showed an odds ratio (OR) of 17.8 [95% confidence interval (CI): 5.7-70.6; p<0.01] for loss of reconstruction, with 15 (30%) in the PRT group and 7 (4%) in the non-PRT group. We found no difference in short-term reoperations or infections at either stage of reconstruction.

CONCLUSION: In patients undergoing delayed breast reconstruction using an expander/implant, radiotherapy is a significant risk factor for loss of reconstruction. It should be considered a relative contraindication for this reconstructive modality, and careful selection and advisement of the patient about the risks of complications and potential need for additional corrective surgery or later autologous breast reconstruction should be discussed.

Original languageEnglish
JournalJournal of plastic, reconstructive & aesthetic surgery : JPRAS
Volume72
Issue number11
Pages (from-to)1763-1768
Number of pages6
ISSN1748-6815
DOIs
Publication statusPublished - Nov 2019

ID: 58926864