Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Deep-learning-based attenuation correction in dynamic [15O]H2O studies using PET/MRI in healthy volunteers

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Early stopping in clinical PET studies: How to reduce expense and exposure

    Research output: Contribution to journalReviewResearchpeer-review

  2. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. False positive rates in positron emission tomography (PET) voxelwise analyses

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Novel Homozygous Truncating Variant Widens the Spectrum of Early-Onset Multisystemic SYNE1 Ataxia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A convolutional neural network for total tumor segmentation in [64Cu]Cu-DOTATATE PET/CT of patients with neuroendocrine neoplasms

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Letter to the Editor. Copenhagen grading of meningioma

    Research output: Contribution to journalLetterResearchpeer-review

  4. Deep learning for Dixon MRI-based attenuation correction in PET/MRI of head and neck cancer patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Quantitative [15O]H2O positron emission tomography (PET) is the accepted reference method for regional cerebral blood flow (rCBF) quantification. To perform reliable quantitative [15O]H2O-PET studies in PET/MRI scanners, MRI-based attenuation-correction (MRAC) is required. Our aim was to compare two MRAC methods (RESOLUTE and DeepUTE) based on ultrashort echo-time with computed tomography-based reference standard AC (CTAC) in dynamic and static [15O]H2O-PET. We compared rCBF from quantitative perfusion maps and activity concentration distribution from static images between AC methods in 25 resting [15O]H2O-PET scans from 14 healthy men at whole-brain, regions of interest and voxel-wise levels. Average whole-brain CBF was 39.9 ± 6.0, 39.0 ± 5.8 and 40.0 ± 5.6 ml/100 g/min for CTAC, RESOLUTE and DeepUTE corrected studies respectively. RESOLUTE underestimated whole-brain CBF by 2.1 ± 1.50% and rCBF in all regions of interest (range -2.4%- -1%) compared to CTAC. DeepUTE showed significant rCBF overestimation only in the occipital lobe (0.6 ± 1.1%). Both MRAC methods showed excellent correlation on rCBF and activity concentration with CTAC, with slopes of linear regression lines between 0.97 and 1.01 and R2 over 0.99. In conclusion, RESOLUTE and DeepUTE provide AC information comparable to CTAC in dynamic [15O]H2O-PET but RESOLUTE is associated with a small but systematic underestimation.

Original languageEnglish
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume41
Issue number12
Pages (from-to)3314-3323
Number of pages10
ISSN0271-678X
DOIs
Publication statusPublished - Dec 2021

    Research areas

  • Adult, Brain/blood supply, Cerebrovascular Circulation, Deep Learning, Humans, Magnetic Resonance Imaging, Male, Oxygen Radioisotopes/administration & dosage, Positron-Emission Tomography, Radiopharmaceuticals/administration & dosage, Water/administration & dosage

ID: 74111955