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Decreased platelet size is associated with platelet activation and anti-phospholipid syndrome in systemic lupus erythematosus

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Susacs syndrom er en vigtig differentialdiagnose ved monosymptomatisk encefalopati hos yngre voksne.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Efficient evaluation of humoral immune responses by the use of serum pools

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. "Kill" the messenger: Targeting of cell-derived microparticles in lupus nephritis

    Research output: Contribution to journalReviewResearchpeer-review

  • Christian Lood
  • Helena Tydén
  • Birgitta Gullstrand
  • Christoffer T Nielsen
  • Niels H H Heegaard
  • Petrus Linge
  • Andreas Jönsen
  • Roger Hesselstrand
  • Robin Kahn
  • Anders A Bengtsson
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Objectives: . SLE is an autoimmune disease with increased cardiovascular morbidity and platelet activation. In the general population, increased platelet size predicts platelet reactivity and cardiovascular disease. The aim of this study was to investigate whether platelet size related to platelet activation and cardiovascular disease in SLE.

Methods: . Fresh blood samples from SLE patients ( n = 148), healthy volunteers ( n = 79) and disease controls ( n = 40) were analysed for platelet size and activation by flow cytometry, ELISA and cell count. Associations to manifest cardiovascular disease, venous thrombosis and APS were adjusted for traditional cardiovascular risk factors using logistic regression analysis.

Results: . SLE patients had decreased platelet size as compared with healthy controls ( P = 0.003). In SLE, decreased platelet size was related to increased platelet activation, in particular microparticle formation ( P < 0.0001, r = -0.46) and release of serotonin from dense granules ( P < 0.001, r = 0.57). SLE patients with aCL had decreased platelet size ( P = 0.02) and aCL decreased platelet size in vitro ( P = 0.007). In contrast to the general population, increased platelet size was not associated with cardiovascular disease. Instead, decreased platelet size was associated with secondary APS, even after adjusting for traditional cardiovascular risk factors ( P = 0.01, odds ratio 3.58).

Conclusion: . Platelet size is decreased in SLE patients and associated with microparticle formation and APS. Future studies are needed to determine the underlying mechanism(s) as well as the potential predictive value of small platelets for disease complications in SLE.

Original languageEnglish
JournalRheumatology (Oxford, England)
Issue number3
Pages (from-to)408-416
Number of pages9
Publication statusPublished - 1 Mar 2017
Externally publishedYes

    Research areas

  • Adult, Aged, Aged, 80 and over, Antibodies, Anticardiolipin, Antiphospholipid Syndrome, Arthritis, Rheumatoid, Blood Platelets, Cardiovascular Diseases, Case-Control Studies, Cell Count, Cell-Derived Microparticles, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Logistic Models, Lupus Erythematosus, Systemic, Male, Middle Aged, Odds Ratio, Platelet Activation, Risk Factors, Scleroderma, Systemic, Serotonin, Venous Thrombosis, Young Adult, Journal Article

ID: 52386669