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Data on administration of cyclosporine, nicorandil, metoprolol on reperfusion related outcomes in ST-segment Elevation Myocardial Infarction treated with percutaneous coronary intervention

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  1. Data on patient-reported outcomes and the risk of readmission following a cardiac diagnosis

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  2. Data on an intervention to reduce readmissions after open heart valve surgery

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  3. Data on the use of dietary supplements in Danish patients with type 1 and type 2 diabetes

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  4. Data on association between QRS duration on prehospital ECG and mortality in patients with confirmed STEMI

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  5. Data on the quantitative assessment pulmonary ground-glass opacification from coronary computed tomography angiography datasets

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  1. Coronary risk of patients with valvular heart disease: prospective validation of CT-Valve Score

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  2. Vascular function in adults with cyanotic congenital heart disease

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  3. Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study

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  4. Ultrasound-assisted thrombolysis for acute intermediate-high-risk pulmonary embolism

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  • Gianluca Campo
  • Rita Pavasini
  • Giampaolo Morciano
  • Michael A Lincoff
  • Michael C Gibson
  • Masafumi Kitakaze
  • Jacob Lonborg
  • Amrita Ahluwalia
  • Hideki Ishii
  • Michael Frenneaux
  • Michel Ovize
  • Marcello Galvani
  • Dan Atar
  • Borja Ibanez
  • Giampaolo Cerisano
  • Simone Biscaglia
  • Brandon J Neil
  • Masanori Asakura
  • Thomas Engstrom
  • Daniel A Jones
  • Dana Dawson
  • Roberto Ferrari
  • Paolo Pinton
  • Filippo Ottani
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Mortality and morbidity in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) are still high [1]. A huge amount of the myocardial damage is related to the mitochondrial events happening during reperfusion [2]. Several drugs directly and indirectly targeting mitochondria have been administered at the time of the PCI and their effect on fatal (all-cause mortality, cardiovascular (CV) death) and non fatal (hospital readmission for heart failure (HF)) outcomes have been tested showing conflicting results [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]. Data from 15 trials have been pooled with the aim to analyze the effect of drug administration versus placebo on outcome [17]. Subgroup analysis are here analyzed: considering only randomized clinical trial (RCT) on cyclosporine or nicorandil [3], [4], [5], [9], [10], [11], excluding a trial on metoprolol [12] and comparing trial with follow-up length <12 months versus those with longer follow-up [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]. This article describes data related article titled "Clinical Benefit of Drugs Targeting Mitochondrial Function as an Adjunct to Reperfusion in ST-segment Elevation Myocardial Infarction: a Meta-Analysis of Randomized Clinical Trials" [17].

Original languageEnglish
JournalData in Brief
Volume14
Pages (from-to)197-205
Number of pages9
ISSN2352-3409
DOIs
Publication statusPublished - Oct 2017

    Research areas

  • Journal Article

ID: 52686661