Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Cytoplasmic mRNPs revisited: Singletons and condensates

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{ad3c6788b7cf45cda722f36de77ba473,
title = "Cytoplasmic mRNPs revisited: Singletons and condensates",
abstract = "Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.",
author = "{\`A}ngels Mateu-Regu{\'e} and Nielsen, {Finn Cilius} and Jan Christiansen",
note = "{\textcopyright} The Authors. BioEssays published by Wiley Periodicals LLC.",
year = "2020",
month = dec,
doi = "10.1002/bies.202000097",
language = "English",
volume = "42",
pages = "e2000097",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John/Wiley & Sons Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Cytoplasmic mRNPs revisited

T2 - Singletons and condensates

AU - Mateu-Regué, Àngels

AU - Nielsen, Finn Cilius

AU - Christiansen, Jan

N1 - © The Authors. BioEssays published by Wiley Periodicals LLC.

PY - 2020/12

Y1 - 2020/12

N2 - Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.

AB - Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.

U2 - 10.1002/bies.202000097

DO - 10.1002/bies.202000097

M3 - Journal article

C2 - 33145808

VL - 42

SP - e2000097

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 12

ER -

ID: 62075248