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Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

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Harvard

Siewert, KM, Klarin, D, Damrauer, SM, Chang, K-M, Tsao, PS, Assimes, TL, Davey Smith, G, Voight, BF, The International Headache Genetics Consortium, Hansen, TF, Olesen, J & Esserlind, A-L 2020, 'Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache', International Journal of Epidemiology, vol. 49, no. 3, pp. 1022-1031. https://doi.org/10.1093/ije/dyaa050

APA

Siewert, K. M., Klarin, D., Damrauer, S. M., Chang, K-M., Tsao, P. S., Assimes, T. L., Davey Smith, G., Voight, B. F., The International Headache Genetics Consortium, Hansen, T. F., Olesen, J., & Esserlind, A-L. (2020). Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. International Journal of Epidemiology, 49(3), 1022-1031. https://doi.org/10.1093/ije/dyaa050

CBE

Siewert KM, Klarin D, Damrauer SM, Chang K-M, Tsao PS, Assimes TL, Davey Smith G, Voight BF, The International Headache Genetics Consortium, Hansen TF, Olesen J, Esserlind A-L. 2020. Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. International Journal of Epidemiology. 49(3):1022-1031. https://doi.org/10.1093/ije/dyaa050

MLA

Vancouver

Author

Siewert, Katherine M ; Klarin, Derek ; Damrauer, Scott M ; Chang, Kyong-Mi ; Tsao, Philip S ; Assimes, Themistocles L ; Davey Smith, George ; Voight, Benjamin F ; The International Headache Genetics Consortium ; Hansen, Thomas Folkmann ; Olesen, Jes ; Esserlind, Ann-Louise. / Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. In: International Journal of Epidemiology. 2020 ; Vol. 49, No. 3. pp. 1022-1031.

Bibtex

@article{e602d25c049940b2bb3a8b4e0fbd943d,
title = "Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache",
abstract = "BACKGROUND: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized.METHODS: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available.RESULTS: We report multiple phenotypes with genetic correlation (P  < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine.CONCLUSIONS: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci.",
keywords = "Genetic Pleiotropy, Genome-Wide Association Study, Humans, Migraine Disorders/epidemiology, Phenotype",
author = "Siewert, {Katherine M} and Derek Klarin and Damrauer, {Scott M} and Kyong-Mi Chang and Tsao, {Philip S} and Assimes, {Themistocles L} and {Davey Smith}, George and Voight, {Benjamin F} and {The International Headache Genetics Consortium} and Hansen, {Thomas Folkmann} and Jes Olesen and Ann-Louise Esserlind",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.",
year = "2020",
month = jun,
day = "1",
doi = "10.1093/ije/dyaa050",
language = "English",
volume = "49",
pages = "1022--1031",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

AU - Siewert, Katherine M

AU - Klarin, Derek

AU - Damrauer, Scott M

AU - Chang, Kyong-Mi

AU - Tsao, Philip S

AU - Assimes, Themistocles L

AU - Davey Smith, George

AU - Voight, Benjamin F

AU - The International Headache Genetics Consortium

A2 - Hansen, Thomas Folkmann

A2 - Olesen, Jes

A2 - Esserlind, Ann-Louise

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - BACKGROUND: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized.METHODS: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available.RESULTS: We report multiple phenotypes with genetic correlation (P  < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine.CONCLUSIONS: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci.

AB - BACKGROUND: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized.METHODS: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available.RESULTS: We report multiple phenotypes with genetic correlation (P  < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine.CONCLUSIONS: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci.

KW - Genetic Pleiotropy

KW - Genome-Wide Association Study

KW - Humans

KW - Migraine Disorders/epidemiology

KW - Phenotype

U2 - 10.1093/ije/dyaa050

DO - 10.1093/ije/dyaa050

M3 - Journal article

C2 - 32306029

VL - 49

SP - 1022

EP - 1031

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 3

ER -

ID: 68507074