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Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

C-reactive protein levels and risk of dementia-Observational and genetic studies of 111,242 individuals from the general population

Research output: Contribution to journalJournal articleResearchpeer-review

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INTRODUCTION: Increased plasma levels of C-reactive protein (CRP) in midlife are associated with increased risk of Alzheimer's disease (AD), whereas in older age the opposite association is observed. Whether genetically determined CRP is associated with AD remains unclear.

METHODS: A total of 111,242 White individuals from the Copenhagen General Population Study and the Copenhagen City Heart Study were included. Plasma levels of CRP and four regulatory genetic variants in the CRP gene were determined.

RESULTS: For CRP percentile group 1 to 5 (lowest plasma CRP) versus the 50 to 75 group (reference), the hazard ratio for AD was 1.69 (95% confidence interval 1.29-2.16). Genetically low CRP was associated with increased risk of AD in individuals with body mass index ≤25 kg/m2 (P = 4 × 10-6 ).

DISCUSSION: Low plasma levels of CRP at baseline were associated with high risk of AD in individuals from the general population. These observational findings were supported by genetic studies.

Original languageEnglish
JournalAlzheimer's & dementia : the journal of the Alzheimer's Association
ISSN1552-5260
DOIs
Publication statusE-pub ahead of print - 3 Feb 2022

Bibliographical note

© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

ID: 79812677