Research
Print page
Switch language
Rigshospitalet
- a part of Copenhagen University Hospital
Published
Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections
Research output: Contribution to journal › Journal article › Research › peer-review
Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.
| Original language | English |
|---|---|
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Volume | 71 |
| Issue number | 7 |
| Pages (from-to) | 1772-1775 |
| Number of pages | 4 |
| ISSN | 1058-4838 |
| DOIs | |
| Publication status | Published - 23 Oct 2020 |
- Streptococcus pyogenes, intravenous immunoglobulin G, necrotizing fasciitis, necrotizing soft tissue infections, superantigens
Research areas
ID: 59138287