Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections - Research - Rigshospitalet

Research

Print page

Print page

Switch language

Rigshospitalet - a part of Copenhagen University Hospital

E-pub ahead of print

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Research output: Contribution to journal › Journal article › Research › peer-review

DOI

https://doi.org/10.1093/cid/ciaa022
Final published version

From the same journal

Increased Risk of Ischemic Stroke After Treatment of Infective Endocarditis: A Danish, Nationwide, Propensity Score-Matched Cohort Study
Research output: Contribution to journal › Journal article › Research › peer-review
The Consensus Hepatitis C Cascade of Care: standardized reporting to monitor progress toward elimination
Research output: Contribution to journal › Journal article › Research › peer-review
Reconciling Antimicrobial Susceptibility Testing and Clinical Response in Antimicrobial Treatment of Chronic Cystic Fibrosis Lung Infections
Research output: Contribution to journal › Journal article › Research › peer-review
First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria
Research output: Contribution to journal › Journal article › Research › peer-review
Controlled Human Malaria Infection of Healthy Adults With Lifelong Malaria Exposure to Assess Safety, Immunogenicity, and Efficacy of the Asexual Blood Stage Malaria Vaccine Candidate GMZ2
Research output: Contribution to journal › Journal article › Research › peer-review

By the same author

Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment
Research output: Contribution to journal › Journal article › Research › peer-review
Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections
Research output: Contribution to journal › Journal article › Research › peer-review
Haloperidol for the treatment of delirium in critically ill patients: a systematic review with meta-analysis and Trial Sequential Analysis
Research output: Contribution to journal › Review › Research › peer-review
Lower versus higher fluid volumes during initial management of sepsis - a systematic review with meta-analysis and trial sequential analysis
Research output: Contribution to journal › Journal article › Research › peer-review
Effects of magnesium, phosphate and zinc supplementation in ICU patients-Protocol for a systematic review
Research output: Contribution to journal › Review › Research › peer-review

INFECT study group

View graph of relations

Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

Original language	English
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/ciaa022
Publication status	E-pub ahead of print - 9 Jan 2020

ID: 59138287