Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections - Research - Rigshospitalet

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Rigshospitalet - a part of Copenhagen University Hospital

E-pub ahead of print

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Research output: Contribution to journal › Journal article › Research › peer-review

DOI

https://doi.org/10.1093/cid/ciaa022
Final published version

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INFECT study group

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Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

Original language	English
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/ciaa022
Publication status	E-pub ahead of print - 9 Jan 2020

ID: 59138287