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Consequences of β-Thalassemia or Sickle Cell Disease for Ovarian Follicle Number and Morphology in Girls Who Had Ovarian Tissue Cryopreserved

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  1. Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation

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  2. Absence of P2Y2 receptor does not prevent bone destruction in a murine model of muscle paralysis-Induced bone loss

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  3. Case Report: Giant Paraganglioma of the Skull Base With Two Somatic Mutations in SDHB and PTEN Genes

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  4. Editorial: Advanced Cardiovascular Imaging in Diabetes

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  5. Expression and Role of INSL3 in the Fetal Testis

    Research output: Contribution to journalReviewResearchpeer-review

  1. Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reintroducing serum FSH measurement during ovarian stimulation for ART

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Fertility preservation in boys facing gonadotoxic cancer therapy

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Women with β-thalassemia (BT) and sickle cell disease (SCD) have a high risk of infertility and premature ovarian insufficiency. Different fertility preserving strategies, including ovarian tissue cryopreservation (OTC) and oocyte cryopreservation has been considered, and healthy babies have been born after successful OTC and transplantation. We evaluated follicle number and follicle health in ovarian tissue from a cohort of BT and SCD patients who underwent OTC before the age of 18 years. Patients undergoing OTC from 2002 to 2019 were included. A total of 14 girls and adolescents with BT and four with SCD, aged 2.8-17.4 years at OTC were included together with a reference group of 43 girls and adolescents with non-anemia diseases considered to have normal ovaries aged 0.6-17.9 years at OTC. Ovarian follicle density was measured in cortex biopsies and compared to the reference group. Expression of proteins associated with follicular health was evaluated using immunohistochemistry. Follicles were detected in the ovarian cortex biopsies from all patients with BT and SCD. The follicle densities were within the 95% prediction interval of the reference group in all cases. A similar expression of six proteins essential for follicular health was detected using immunohistochemistry in BT, SCD, and references. OTC should be considered an option for young girls and adolescents with BT and SCD.

Original languageEnglish
Article number593718
JournalFrontiers in Endocrinology
Volume11
Pages (from-to)593718
ISSN1664-2392
DOIs
Publication statusPublished - 2021

Bibliographical note

Copyright © 2021 Mamsen, Kristensen, Pors, Bøtkjær, Ernst, Macklon, Gook, Kumar, Kalra and Andersen.

    Research areas

  • Adolescent, Adult, Anemia, Sickle Cell/complications, Case-Control Studies, Child, Child, Preschool, Cryopreservation/methods, Female, Fertility Preservation/methods, Humans, Infant, Infertility, Female/therapy, Oocytes/cytology, Ovarian Follicle/cytology, Young Adult, beta-Thalassemia/complications

ID: 75234428