Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital

Cone photoreceptor density in the Copenhagen Child Cohort at age 16-17 years

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Retinal layer segmentation in rodent OCT images: Local intensity profiles & fully convolutional neural networks

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  3. Progression Over 5 Years of Prelaminar Hyperreflective Lines to Optic Disc Drusen in the Copenhagen Child Cohort 2000 Eye Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: To examine cone density in relation to gestational and morphological parameters in the Copenhagen Child Cohort (CCC2000).

METHODS: The macula was imaged using adaptive optics in 1,296 adolescents aged 16-17 years. Axial length and distance visual acuity were determined. Absolute and angular cone photoreceptor density were analysed for an 80 × 80-pixel area, 2 degrees temporal to the fovea. Association with axial length was analysed with linear regression. Correlation with visual acuity was described with a Pearson correlation coefficient. Associations of cone density with gestational parameters, maternal smoking, sex and age were analysed using multiple regression adjusted for axial length.

RESULTS: Mean absolute cone density was 30,007 cones/mm2 (SD ± 3,802) and mean angular cone density was 2,383 cones/deg2 (SD ± 231). Peri- and postnatal parameters, sex and age had no statistically significant effect on cone density (p > 0.05). Absolute cone density decreased with longer axial length (-2,855 cones/mm2 per mm or -9.7% per mm, p < 0.0001). For angular density, which included a correction for the geometrical enlargement of the eye with axial length, a decrease with axial length was detectable, but it was small (-20 cones/deg2 per mm or -0.84% per mm, p = 0.009).

CONCLUSIONS: The decrease in cone density per unit solid angle with increasing axial length was small, less than 1 percent per mm, indicating that expansion of the posterior pole during the development of refraction takes place without a clinically significant loss of cones. Perinatal parameters, within the spectrum presented by the study population, had no detectable effect on cone density.

Original languageEnglish
JournalOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Issue number6
Pages (from-to)1292-1299
Number of pages8
Publication statusPublished - Nov 2021

Bibliographical note

© 2021 The Authors Ophthalmic and Physiological Optics © 2021 The College of Optometrists.

ID: 68335106