Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Computed tomography quantification of emphysema in people living with HIV and uninfected controls

Research output: Contribution to journalJournal articleResearchpeer-review

  1. NORDSTAR - Paving the way for a new era in asthma research

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. ERS/TSANZ Task Force Statement on the Management of Reproduction and Pregnancy in Women with Airways Diseases

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Latent tuberculosis infection among minor asylum seekers in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genome-wide association study of high-sensitivity C-reactive protein, D-dimer and Interleukin-6 levels in multi-ethnic HIV+ cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Left ventricular myocardial crypts: morphological patterns and prognostic implications

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

People living with HIV (PLWH) may be more susceptible to the development of emphysema than uninfected individuals. We assessed prevalence and risk factors for emphysema in PLWH and uninfected controls. Spirometry and chest computed tomography scans were obtained in PLWH from the Copenhagen comorbidity in HIV infection (COCOMO) Study and in uninfected controls from the Copenhagen General Population Study (CGPS) who were aged above 40 years. Emphysema was quantified using low attenuation area below -950 Hounsfield units (%LAA-950), the 15th percentile density index (PD15) and assessed by semi-quantitative visual scales. Of 742 PLWH, 21.2% and 4.7% had emphysema according to the %LAA-950 threshold with cut-offs at 5% and 10%, respectively. Of 470 uninfected controls, these numbers were 24.3% (p=0.23) and 4.0% (p=0.68). HIV was not associated with emphysema (adjusted odds ratio 1.25 [95%CI: 0.68-2.36] for %LAA-950>10%), by PD15, or by visually assessed emphysema. We found no interaction between HIV and cumulative smoking. Breathlessness and sputum production were more common in PLWH with emphysema, and emphysema seemed to be more prevalent in PLWH with airflow limitation. HIV was therefore not independently associated with emphysema but the clinical impact of emphysema was greater in PLWH than in uninfected controls.

Original languageEnglish
JournalThe European Respiratory Journal
Volume52
Issue number1
Pages (from-to)1800296
ISSN0903-1936
DOIs
Publication statusPublished - 2018

ID: 54604116