Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Biofilm formation - what we can learn from recent developments

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence and clinical significance of neutropenia discovered in routine complete blood cell counts: a longitudinal study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Red blood cell transfusion in surgery: an observational study of the trends in the USA from 2011 to 2016

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase-Lowering Effect of a HSD17B13 Variant

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of LDL cholesterol on microvascular versus macrovascular disease: A Mendelian Randomization Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Residual vascular risk in diabetes - Will the SPPARM alpha concept hold the key?

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND AND OBJECTIVES: Coffee intake is associated with low risk of symptomatic gallstone disease (GSD). We tested the hypothesis that high coffee intake causally protects against symptomatic GSD using a Mendelian randomization design.

METHODS: First, we tested whether high coffee intake was associated with low risk of GSD in 104 493 individuals from the general population. Mean follow-up was 8 years (range: <1-13 years). Secondly, we tested whether two genetic variants near CYP1A1/A2 (rs2472297) and AHR (rs4410790), combined as an allele score, were associated with higher coffee intake measured as a continuous variable. Thirdly, we tested whether the allele score was associated with lower risk of GSD in 114 220 individuals including 7294 gallstone events. Mean follow-up was 38 years (range: <1-40 years).

RESULTS: In observational analysis, those with coffee intake of >6 cups daily had 23% lower risk of GSD compared to individuals without coffee intake [hazard ratio (HR) = 0.77 (95% confidence interval: 0.61-0.94)]. In genetic analysis, there was a stepwise higher coffee intake of up to 41% (caffeine per day) in individuals with 4 (highest) versus 0 (lowest) coffee intake alleles (P for trend = 3 x 10-178 ) and a corresponding stepwise lower risk of GSD up to 19%[HR = 0.81 (0.69-0.96)]. The estimated observational odds ratio for GSD for a one cup per day higher coffee intake was 0.97 (0.96-0.98), equal to 3% lower risk. The corresponding genetic odds ratio was 0.89 (0.83-0.95), equal to 11% lower risk.

CONCLUSION: High coffee intake is associated observationally with low risk of GSD, and with genetic evidence to support a causal relationship.

Original languageEnglish
JournalJournal of Internal Medicine
Volume287
Issue number1
Pages (from-to)42-53
Number of pages12
ISSN0954-6820
DOIs
Publication statusPublished - Jan 2020

ID: 59307516