Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Clinically isolated laryngeal sarcoidosis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Developing a national e-learning course in otorhinolaryngology: the Danish experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Ultra-high-fidelity virtual reality mastoidectomy simulation training: a randomized, controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. FDG-PET/CT in the surveillance of head and neck cancer following radiotherapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Value of pre- and intraoperative diagnostic methods in suspected glottic neoplasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome

    Research output: Contribution to journalReviewResearchpeer-review

  2. Calcium electroporation for recurrent head and neck cancer: A clinical phase I study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Endoscopic electrochemotherapy for esophageal cancer: a phase I clinical study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Cold-Steel Phonosurgery of Reinke Edema Evaluated by the Multidimensional Voice Program

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Laryngeal sarcoidosis is rare (0.5% of patients with sarcoidosis), the pathogenesis is unknown and the optimal treatment remains a matter of debate. We undertook this study to elucidate possible pathogenic factors in clinically isolated laryngeal sarcoidosis and to describe results of supraglottoplastic surgery. From 1995 to 2009, we identified six patients with histologically proven sarcoidosis of the larynx treated at Rigshospitalet. All patients were subjected to a panel of blood tests and MR scan of the head and neck. All patients had dyspnoea at admission, and five were subjected to a combination of CO(2)-laser excision of supraglottic tissue and closure of the incision with sutures. All serological tests were negative or normal, including angiotensin 1 converting enzyme. The clinical expression was uniform with pale, smooth swellings of the supraglottic structures. Surgery proved successful to maintain normal breathing. None of the many parameters examined--some previously having been found to be abnormal in sarcoidosis--were abnormal in the present cohort. We are therefore unable to elucidate the pathogenesis. The combined surgical approach re-established normal airway function for all five patients and complete remission without further swellings was seen in two patients.
Original languageEnglish
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume268
Issue number4
Pages (from-to)575-80
Number of pages6
ISSN0937-4477
DOIs
Publication statusPublished - 2011

    Research areas

  • Adolescent, Adult, Biopsy, Diagnosis, Differential, Female, Glucocorticoids, Humans, Laryngeal Diseases, Laryngoscopy, Laser Therapy, Lasers, Gas, Magnetic Resonance Imaging, Male, Retrospective Studies, Sarcoidosis, Treatment Outcome, Young Adult

ID: 34704023