Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Clinical proteomics: Insights from IGF-I

Research output: Contribution to journalReviewpeer-review

  1. Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reference values for leptin/adiponectin ratio in healthy children and adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Validation of image cytometry for sperm concentration measurement: Comparison with manual counting of 4010 human semen samples

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Clinical usefulness of bone turnover marker concentrations in osteoporosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty: A study from the Odense Child Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Insulin-like growth factor-I predicts sinusoidal obstruction syndrome following pediatric hematopoietic stem cell transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Modified-release Hydrocortisone in Congenital Adrenal Hyperplasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The influence of prenatal exposure to phthalates on subsequent male growth and body composition in adolescence

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Clinical proteomics aims to deliver cost-effective multiplexing of potentially hundreds of diagnostic proteins, including distinct protein isoforms. The analytical strategy known as targeted proteomics is particularly promising because it is compatible with robust mass spectrometry (MS)-platforms already implemented in many clinical laboratories for routine quantitation of small molecules (i.e. uHPLC coupled to triple-quadrupole MS). Progress in targeted proteomics of circulating insulin-like growth factor 1 (IGF-I) have provided valuable insights about tryptic peptides, transitions, internal standards and calibrants. The present challenge is to examine if targeted proteomics of IGF-I can truly measure up to the routine performance that must be expected from a clinical testing platform.

Original languageEnglish
JournalClinica chimica acta; international journal of clinical chemistry
Volume477
Pages (from-to)18-23
Number of pages6
ISSN0009-8981
DOIs
Publication statusPublished - Feb 2018

    Research areas

  • Journal Article, Review

ID: 52794201