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Rigshospitalet - a part of Copenhagen University Hospital
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Circadian rhythms of mineral metabolism in chronic kidney disease-mineral bone disorder

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  1. New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Challenges and opportunities for nephrology in Western Europe

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

    Research output: Contribution to journalJournal articleResearchpeer-review

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PURPOSE OF REVIEW: The circadian rhythms have a systemic impact on all aspects of physiology. Kidney diseases are associated with extremely high-cardiovascular mortality, related to chronic kidney disease-mineral bone disorder (CKD-MBD), involving bone, parathyroids and vascular calcification. Disruption of circadian rhythms may cause serious health problems, contributing to development of cardiovascular diseases, metabolic syndrome, cancer, organ fibrosis, osteopenia and aging. Evidence of disturbed circadian rhythms in CKD-MBD parameters and organs involved is emerging and will be discussed in this review.

RECENT FINDINGS: Kidney injury induces unstable behavioral circadian rhythm. Potentially, uremic toxins may affect the master-pacemaker of circadian rhythm in hypothalamus. In CKD disturbances in the circadian rhythms of CKD-MBD plasma-parameters, activin A, fibroblast growth factor 23, parathyroid hormone, phosphate have been demonstrated. A molecular circadian clock is also expressed in peripheral tissues, involved in CKD-MBD; vasculature, parathyroids and bone. Expression of the core circadian clock genes in the different tissues is disrupted in CKD-MBD.

SUMMARY: Disturbed circadian rhythms is a novel feature of CKD-MBD. There is a need to establish which specific input determines the phase of the local molecular clock and to characterize its regulation and deregulation in tissues involved in CKD-MBD. Finally, it is important to establish what are the implications for treatment including the potential applications for chronotherapy.

Original languageEnglish
JournalCurrent opinion in nephrology and hypertension
Volume29
Issue number4
Pages (from-to)367-377
Number of pages11
ISSN1062-4821
DOIs
Publication statusPublished - Jul 2020

ID: 61259820