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Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry

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Harvard

Ntaios, G, Michel, P, Georgiopoulos, G, Guo, Y, Li, W, Xiong, J, Calleja, P, Ostos, F, González-Ortega, G, Fuentes, B, Alonso de Leciñana, M, Díez-Tejedor, E, García-Madrona, S, Masjuan, J, DeFelipe, A, Turc, G, Gonçalves, B, Domigo, V, Dan, G-A, Vezeteu, R, Christensen, H, Christensen, LM, Meden, P, Hajdarevic, L, Rodriguez-Lopez, A, Díaz-Otero, F, García-Pastor, A, Gil-Nuñez, A, Maslias, E, Strambo, D, Werring, DJ, Chandratheva, A, Benjamin, L, Simister, R, Perry, R, Beyrouti, R, Jabbour, P, Sweid, A, Tjoumakaris, S, Cuadrado-Godia, E, Campello, AR, Roquer, J, Moreira, T, Mazya, MV, Bandini, F, Matz, K, Iversen, HK, González-Duarte, A, Tiu, C, Ferrari, J, Vosko, MR, Salzer, HJF, Lamprecht, B, Dünser, MW, Cereda, CW, Quintero, ÁBC, Korompoki, E, Soriano-Navarro, E, Soto-Ramírez, LE, Castañeda-Méndez, PF, Bay-Sansores, D, Arauz, A, Cano-Nigenda, V, Kristoffersen, ES, Tiainen, M, Strbian, D, Putaala, J & Lip, GYH 2020, 'Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry' Stroke, vol. 51, no. 9, pp. e254-e258. https://doi.org/10.1161/STROKEAHA.120.031208

APA

Ntaios, G., Michel, P., Georgiopoulos, G., Guo, Y., Li, W., Xiong, J., ... Lip, G. Y. H. (2020). Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry. Stroke, 51(9), e254-e258. https://doi.org/10.1161/STROKEAHA.120.031208

CBE

Ntaios G, Michel P, Georgiopoulos G, Guo Y, Li W, Xiong J, Calleja P, Ostos F, González-Ortega G, Fuentes B, Alonso de Leciñana M, Díez-Tejedor E, García-Madrona S, Masjuan J, DeFelipe A, Turc G, Gonçalves B, Domigo V, Dan G-A, Vezeteu R, Christensen H, Christensen LM, Meden P, Hajdarevic L, Rodriguez-Lopez A, Díaz-Otero F, García-Pastor A, Gil-Nuñez A, Maslias E, Strambo D, Werring DJ, Chandratheva A, Benjamin L, Simister R, Perry R, Beyrouti R, Jabbour P, Sweid A, Tjoumakaris S, Cuadrado-Godia E, Campello AR, Roquer J, Moreira T, Mazya MV, Bandini F, Matz K, Iversen HK, González-Duarte A, Tiu C, Ferrari J, Vosko MR, Salzer HJF, Lamprecht B, Dünser MW, Cereda CW, Quintero ÁBC, Korompoki E, Soriano-Navarro E, Soto-Ramírez LE, Castañeda-Méndez PF, Bay-Sansores D, Arauz A, Cano-Nigenda V, Kristoffersen ES, Tiainen M, Strbian D, Putaala J, Lip GYH. 2020. Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry. Stroke. 51(9):e254-e258. https://doi.org/10.1161/STROKEAHA.120.031208

MLA

Vancouver

Author

Ntaios, George ; Michel, Patrik ; Georgiopoulos, Georgios ; Guo, Yutao ; Li, Wencheng ; Xiong, Jing ; Calleja, Patricia ; Ostos, Fernando ; González-Ortega, Guillermo ; Fuentes, Blanca ; Alonso de Leciñana, María ; Díez-Tejedor, Exuperio ; García-Madrona, Sebastian ; Masjuan, Jaime ; DeFelipe, Alicia ; Turc, Guillaume ; Gonçalves, Bruno ; Domigo, Valerie ; Dan, Gheorghe-Andrei ; Vezeteu, Roxana ; Christensen, Hanne ; Christensen, Louisa Marguerite ; Meden, Per ; Hajdarevic, Lejla ; Rodriguez-Lopez, Angela ; Díaz-Otero, Fernando ; García-Pastor, Andrés ; Gil-Nuñez, Antonio ; Maslias, Errikos ; Strambo, Davide ; Werring, David J ; Chandratheva, Arvind ; Benjamin, Laura ; Simister, Robert ; Perry, Richard ; Beyrouti, Rahma ; Jabbour, Pascal ; Sweid, Ahmad ; Tjoumakaris, Stavropoula ; Cuadrado-Godia, Elisa ; Campello, Ana Rodríguez ; Roquer, Jaume ; Moreira, Tiago ; Mazya, Michael V ; Bandini, Fabio ; Matz, Karl ; Iversen, Helle K ; González-Duarte, Alejandra ; Tiu, Cristina ; Ferrari, Julia ; Vosko, Milan R ; Salzer, Helmut J F ; Lamprecht, Bernd ; Dünser, Martin W ; Cereda, Carlo W ; Quintero, Ángel Basilio Corredor ; Korompoki, Eleni ; Soriano-Navarro, Eduardo ; Soto-Ramírez, Luis Enrique ; Castañeda-Méndez, Paulo F ; Bay-Sansores, Daniela ; Arauz, Antonio ; Cano-Nigenda, Vanessa ; Kristoffersen, Espen Saxhaug ; Tiainen, Marjaana ; Strbian, Daniel ; Putaala, Jukka ; Lip, Gregory Y H. / Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke : The Global COVID-19 Stroke Registry. In: Stroke. 2020 ; Vol. 51, No. 9. pp. e254-e258.

Bibtex

@article{c3a6f5fbd18d4707aaa826697b239267,
title = "Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry",
abstract = "Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9{\%} females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95{\%} CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6{\%}) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51{\%}) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95{\%} CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes.",
keywords = "Aged, Aged, 80 and over, Brain Ischemia/complications, Cohort Studies, Coronavirus Infections/complications, Disability Evaluation, Female, Humans, Male, Middle Aged, Pandemics, Pneumonia, Viral/complications, Propensity Score, Recovery of Function, Registries, Stroke/complications, Survival Analysis, Time-to-Treatment, Tomography, X-Ray Computed, Treatment Outcome, COVID-19, prognosis, Coronavirus, survivors, propensity score",
author = "George Ntaios and Patrik Michel and Georgios Georgiopoulos and Yutao Guo and Wencheng Li and Jing Xiong and Patricia Calleja and Fernando Ostos and Guillermo Gonz{\'a}lez-Ortega and Blanca Fuentes and {Alonso de Leci{\~n}ana}, Mar{\'i}a and Exuperio D{\'i}ez-Tejedor and Sebastian Garc{\'i}a-Madrona and Jaime Masjuan and Alicia DeFelipe and Guillaume Turc and Bruno Gon{\cc}alves and Valerie Domigo and Gheorghe-Andrei Dan and Roxana Vezeteu and Hanne Christensen and Christensen, {Louisa Marguerite} and Per Meden and Lejla Hajdarevic and Angela Rodriguez-Lopez and Fernando D{\'i}az-Otero and Andr{\'e}s Garc{\'i}a-Pastor and Antonio Gil-Nu{\~n}ez and Errikos Maslias and Davide Strambo and Werring, {David J} and Arvind Chandratheva and Laura Benjamin and Robert Simister and Richard Perry and Rahma Beyrouti and Pascal Jabbour and Ahmad Sweid and Stavropoula Tjoumakaris and Elisa Cuadrado-Godia and Campello, {Ana Rodr{\'i}guez} and Jaume Roquer and Tiago Moreira and Mazya, {Michael V} and Fabio Bandini and Karl Matz and Iversen, {Helle K} and Alejandra Gonz{\'a}lez-Duarte and Cristina Tiu and Julia Ferrari and Vosko, {Milan R} and Salzer, {Helmut J F} and Bernd Lamprecht and D{\"u}nser, {Martin W} and Cereda, {Carlo W} and Quintero, {{\'A}ngel Basilio Corredor} and Eleni Korompoki and Eduardo Soriano-Navarro and Soto-Ram{\'i}rez, {Luis Enrique} and Casta{\~n}eda-M{\'e}ndez, {Paulo F} and Daniela Bay-Sansores and Antonio Arauz and Vanessa Cano-Nigenda and Kristoffersen, {Espen Saxhaug} and Marjaana Tiainen and Daniel Strbian and Jukka Putaala and Lip, {Gregory Y H}",
year = "2020",
month = "9",
doi = "10.1161/STROKEAHA.120.031208",
language = "English",
volume = "51",
pages = "e254--e258",
journal = "Journal of Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams & Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke

T2 - The Global COVID-19 Stroke Registry

AU - Ntaios, George

AU - Michel, Patrik

AU - Georgiopoulos, Georgios

AU - Guo, Yutao

AU - Li, Wencheng

AU - Xiong, Jing

AU - Calleja, Patricia

AU - Ostos, Fernando

AU - González-Ortega, Guillermo

AU - Fuentes, Blanca

AU - Alonso de Leciñana, María

AU - Díez-Tejedor, Exuperio

AU - García-Madrona, Sebastian

AU - Masjuan, Jaime

AU - DeFelipe, Alicia

AU - Turc, Guillaume

AU - Gonçalves, Bruno

AU - Domigo, Valerie

AU - Dan, Gheorghe-Andrei

AU - Vezeteu, Roxana

AU - Christensen, Hanne

AU - Christensen, Louisa Marguerite

AU - Meden, Per

AU - Hajdarevic, Lejla

AU - Rodriguez-Lopez, Angela

AU - Díaz-Otero, Fernando

AU - García-Pastor, Andrés

AU - Gil-Nuñez, Antonio

AU - Maslias, Errikos

AU - Strambo, Davide

AU - Werring, David J

AU - Chandratheva, Arvind

AU - Benjamin, Laura

AU - Simister, Robert

AU - Perry, Richard

AU - Beyrouti, Rahma

AU - Jabbour, Pascal

AU - Sweid, Ahmad

AU - Tjoumakaris, Stavropoula

AU - Cuadrado-Godia, Elisa

AU - Campello, Ana Rodríguez

AU - Roquer, Jaume

AU - Moreira, Tiago

AU - Mazya, Michael V

AU - Bandini, Fabio

AU - Matz, Karl

AU - Iversen, Helle K

AU - González-Duarte, Alejandra

AU - Tiu, Cristina

AU - Ferrari, Julia

AU - Vosko, Milan R

AU - Salzer, Helmut J F

AU - Lamprecht, Bernd

AU - Dünser, Martin W

AU - Cereda, Carlo W

AU - Quintero, Ángel Basilio Corredor

AU - Korompoki, Eleni

AU - Soriano-Navarro, Eduardo

AU - Soto-Ramírez, Luis Enrique

AU - Castañeda-Méndez, Paulo F

AU - Bay-Sansores, Daniela

AU - Arauz, Antonio

AU - Cano-Nigenda, Vanessa

AU - Kristoffersen, Espen Saxhaug

AU - Tiainen, Marjaana

AU - Strbian, Daniel

AU - Putaala, Jukka

AU - Lip, Gregory Y H

PY - 2020/9

Y1 - 2020/9

N2 - Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95% CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes.

AB - Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95% CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes.

KW - Aged

KW - Aged, 80 and over

KW - Brain Ischemia/complications

KW - Cohort Studies

KW - Coronavirus Infections/complications

KW - Disability Evaluation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pandemics

KW - Pneumonia, Viral/complications

KW - Propensity Score

KW - Recovery of Function

KW - Registries

KW - Stroke/complications

KW - Survival Analysis

KW - Time-to-Treatment

KW - Tomography, X-Ray Computed

KW - Treatment Outcome

KW - COVID-19

KW - prognosis

KW - Coronavirus

KW - survivors

KW - propensity score

UR - http://www.scopus.com/inward/record.url?scp=85088643004&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.120.031208

DO - 10.1161/STROKEAHA.120.031208

M3 - Journal article

VL - 51

SP - e254-e258

JO - Journal of Stroke

JF - Journal of Stroke

SN - 0039-2499

IS - 9

ER -

ID: 60887382