Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Changes in intracranial pressure and pulse wave amplitude during postural shifts

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk factors for need of reoperation in bilateral chronic subdural haematomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Living with the cerebellar mutism syndrome: long-term challenges of the diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Past, present and future, the experience of time during examination for malignant brain tumor: a qualitative observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Surgical occlusion of middle meningeal artery in treatment of chronic subdural haematoma: anatomical and technical considerations

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Long-term telemetric intracerebral pressure monitoring as a tool in intracranial hypotension

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Living with the cerebellar mutism syndrome: long-term challenges of the diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-term telemetric intracerebral pressure monitoring as a tool in intracranial hypotension

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Randomized blinded trial of automated REBOA during CPR in a porcine model of cardiac arrest

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Monitoring of intracranial pressure (ICP) and ICP pulse wave amplitude (PWA) is an integrated part of neurosurgery. An increase in ICP usually leads to an increase in PWA. These findings have yet to be replicated during the positional shift from supine to upright, where we only know that ICP decreases. Our main aim is to clarify whether the positional shift also results in a change in pulse wave amplitude.

METHOD: Our database was retrospectively reviewed for subjects having had a standardized investigation of positional ICP. In all subjects, mean ICP and PWA were determined with both an automatic and a manual method and compared using Student's t test. Finally, ICP and PWA were tested for correlation in both in supine and upright position.

RESULTS: The study included 29 subjects. A significant change in ICP (Δ14.1 mmHg, p < 0.01) and no significant change in PWA (Δ0.4 mmHg, p = 0.06) were found. Furthermore, a linear correlation between ICP and PWA was found in both supine and upright positions (p < 0.01).

CONCLUSIONS: We found that during the positional shift from supine to upright, ICP is reduced while PWA remains unaffected. This indicates that the pressure-volume curve is shifted downward according to a hydrostatic pressure offset, while the slope of the curve does not change. In addition, the correlation between ICP and PWA in both supine and upright position validates the previous research on the matter.

Original languageEnglish
JournalActa Neurochirurgica
Volume162
Issue number12
Pages (from-to)2983-2989
Number of pages7
ISSN0001-6268
DOIs
Publication statusPublished - Dec 2020

ID: 61346678