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Rigshospitalet - a part of Copenhagen University Hospital
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CGRP in human models of primary headaches

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OBJECTIVE: To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions.

DISCUSSION: Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown.

CONCLUSION: Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume38
Issue number2
Pages (from-to)353-360
ISSN0333-1024
DOIs
Publication statusPublished - 2018

ID: 49696251